SAB4300118
抗-磷酸-LCK (pTyr394) 兔抗
affinity isolated antibody
别名:
抗-YT16 兔抗, 抗-p56lck 兔抗, 抗-pp58lck 兔抗, 抗-淋巴细胞特异性蛋白酪氨酸激酶 兔抗
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
mouse, rat, human
Citations:
4
Technique(s):
western blot: 1:500-1:1000
Uniprot accession no.:
产品名称
抗-磷酸-LCK (pTyr394) 兔抗, affinity isolated antibody
Quality Level
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~56 kDa
species reactivity
mouse, rat, human
concentration
1 mg/mL
technique(s)
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(N-E-YP-T-A)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr394)
Gene Information
human ... LCK(3932)
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
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General description
酪氨酸激酶对胸腺中发育的 T 细胞的选择和成熟，以及和成熟 T 细胞功能中起着重要作用。它与 CD4 和 CD8 表面受体的胞质部分组成性相关，并在 T 细胞抗原受体（TCR）相关的信号转导途径中起重要作用。TCR 与结合肽抗原的 MHC 复合物的结合分别促进 CD4 和 CD8 与 MHC II 类和 I 类分子的相互作用，从而将相关的 LCK 募集到 TCR/CD3 复合物附近。然后，LCK 将 TCRgamma 链和 CD3 亚基的胞质尾部中基于免疫受体酪氨酸的激活基序（ITAM）中的酪氨酸残基磷酸化，从而启动 TCR/CD3 信号传导途径。另外，有助于其他受体分子的信号传导。直接与 CD2 的胞质尾区结合，并在 CD2 分子结合后，LCK 发生过度磷酸化和激活。在控制 T 细胞增殖反应的 IL2 受体相关信号通路中也起作用。IL2 与其受体的结合导致 LCK 活性增加。在胸腺细胞发育的所有阶段表达，并且是受前 TCR 和成熟 αβTCR 共同控制的成熟事件的调节所必需的。
Immunogen
源自蛋白 LCK，酪氨酸 393（N-E-Y（p）-T-A）磷酸化位点周围的肽序列。
Physical form
溶于含有0.02％叠氮化钠和50%甘油的磷酸盐缓冲盐水
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Rebekah L Browning et al.
Cancer immunology research, 4(8), 698-707 (2016-06-12)
The immunomodulatory drug lenalidomide has demonstrated efficacy in patients with chronic lymphocytic leukemia (CLL), despite a lack of direct cytotoxic effects in vitro The mechanism of lenalidomide efficacy in vivo is thought to occur via a combination of enhanced immune
Le Han et al.
Acta pharmacologica Sinica, 41(6), 800-812 (2020-01-16)
IgD-Fc-Ig fusion protein, a new biological agent, is constructed by linking a segment of human IgD-Fc with a segment of human IgG1-Fc, which specifically blocks the IgD-IgDR pathway and selectively inhibits the abnormal proliferation, activation, and differentiation of T cells.
Aurélie Le Page et al.
Cell communication and signaling : CCS, 12, 2-2 (2014-01-11)
Immune responses are generally impaired in aged mammals. T cells have been extensively studied in this context due to the initial discovery of their reduced proliferative capacity with aging. The decreased responses involve altered signaling events associated with the early
Sicheng Fu et al.
Nature communications, 11(1), 438-438 (2020-01-25)
Dysfunction of invariant natural killer T (iNKT) cells in tumor microenvironment hinders their anti-tumor efficacy, and the underlying mechanisms remain unclear. Here we report that iNKT cells increase lipid biosynthesis after activation, and that is promoted by PPARγ and PLZF
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