SAB4300124
抗-磷酸化-JAK2 (pTyr1007) 兔抗
affinity isolated antibody
别名:
Anti-JTK10 antibody produced in rabbit, Anti-Janus kinase 2 (a protein tyrosine kinase) antibody produced in rabbit
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p), WB
Citations:
13
isotype
IgG
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~125 kDa
species reactivity
mouse, rat, human
concentration
1 mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100, western blot: 1:500-1:1000
immunogen sequence
(K-E-YP-Y-K)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr1007)
Quality Level
Gene Information
human ... JAK2(3717)
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General description
Janus kinase 2(JAK2) mapped on human chromosome 9p24, encodes a tyrosine kinase. The encoded protein is a member of the Jak family of protein. JAK2 is ubiquitously expressed. This protein contains a catalytic domain and protein–protein interaction domain.
Plays a role in leptin signaling and control of body weight.
Immunogen
Peptide sequence around phosphorylation site of tyrosine 1007 (K-E-Y(p)-Y-K), according to the protein JAK2.
Biochem/physiol Actions
Janus kinase 2(JAK2) plays an important role in the activities of cytokines receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy. In addition, mutations in the gene has also been observed in polycythaemia vera patients.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
A TEL-JAK2 Fusion Protein with Constitutive
Kinase Activity in Human Leukemia
Lacronique V
Science, 278, 1309-1312 (1997)
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
Shin DS
Cancer Discovery, 7, 188-201 (2017)
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
Parganas E
Cell, 93, 385-395 (1998)
Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2.
Joos S
International Journal of Cancer. Journal International Du Cancer, 103, 489-495 (2003)
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
James C
Nature, 434, 1144-1148 (2005)
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