SAB4300458
Anti-RPS6KA5 (Ab-376) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-MGC1911 antibody produced in rabbit, Anti-MSK1 antibody produced in rabbit, Anti-MSPK1 antibody produced in rabbit, Anti-RLPK antibody produced in rabbit, Anti-ribosomal protein S6 kinase, 90kDa, polypeptide 5 antibody produced in rabbit
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
human
Citations:
4
Technique(s):
western blot: 1:500-1:1000
Uniprot accession no.:
产品名称
Anti-RPS6KA5 (Ab-376) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~90 kDa
species reactivity
human
concentration
1 mg/mL
technique(s)
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(G-Y-S-F-V)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... RPS6KA5(9252)
Biochem/physiol Actions
RPS6KA5 (ribosomal protein S6 kinase A5)/mitogen- and stress-activated kinase 1 (MSK1) acts as a connector between extracellular signals and gene expression. It helps in the phosphorylation of chromatin protein histone H3 and high mobility group 14 (HMG14) . MSK1 plays a key role in the development of hormone-dependent breast cancer.
Features and Benefits
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General description
RPS6KA5 (ribosomal protein S6 kinase A5)/mitogen- and stress-activated kinase 1 (MSK1) is a nuclear serine/threonine protein kinase , that is located on human chromosome 14q32. It is a dual kinase domain protein.
Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
Immunogen
Peptide sequence around aa. 374-378 (G-Y-S-F-V), according to the protein RPS6KA5.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS
McCoy CE, et al.
The Biochemical Journal, 402(3), 491-501 (2007)
Activation of mitogen- and stress-activated kinase 1 is required for proliferation of breast cancer cells in response to estrogens or progestins
Reyes D, et al.
Oncogene, 33(12), 1570-1580 (2014)
Mitogen- and stress-activated Kinase 1 mediates Epstein-Barr virus latent membrane protein 1-promoted cell transformation in nasopharyngeal carcinoma through its induction of Fra-1 and c-Jun gene
Li B, et al.
BMC Cancer, 15:390 (2015)
Prenatal diagnosis and molecular cytogenetic characterization of a de novo interstitial duplication of 14q (14q31.3?q32.12) associated with abnormal maternal serum biochemistry
Chen CP, et al.
Taiwanese Journal of Obstetrics & Gynecology, 52(1), 125-128 (2013)
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