SAB4301167
Anti-MTFP1 antibody produced in rabbit
affinity isolated antibody
别名:
HSPC242, MTP18
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
18 kDa
species reactivity
human, mouse
concentration
1.8 mg/mL
technique(s)
immunohistochemistry: 1:50- 1:200, western blot: 1:500-1:2000 (Cell Lysate)
isotype
IgG
accession no.
NP_001003704.1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MTFP1(51537)
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General description
Mitochondrial fission process 1/mitochondrial 18 kDa protein (MTFP1/MTP18), a nuclear-encoded integral protein, is located in the mitochondria. It is also a phosphatidylinositol 3-kinase-dependent protein. MTP18 comprises three α-helical stretches or transmembrane (TM) domains of high hydrophobicity. The MTFP1 gene is located on human chromosome 22q12.2.
Immunogen
Fusion protein corresponding to a region derived from internal residues of human mitochondrial fission process 1
Application
Anti-MTFP1 antibody produced in rabbit has been used in western blot (1:1000).
Biochem/physiol Actions
Mitochondrial fission process 1/mitochondrial 18 kDa protein (MTFP1/MTP18) controls mitochondrial fission Hence it helps to maintain the morphology of the mitochondria. Overexpression of MTP18 can facilitate fragmentation of the mitochondria. Loss-of-function of MTFP1 protein promotes cell death. It is crucial for cell viability.
The antibody detects endogenous levels of total MTFP1 protein.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Daniel Tondera et al.
Journal of cell science, 118(Pt 14), 3049-3059 (2005-06-30)
Mitochondria are dynamic organelles that change morphology by controlled fission and fusion events. Mitochondrial fission is regulated by a conserved protein complex assembled at the outer membrane. Human MTP18 is a novel nuclear-encoded mitochondrial membrane protein, implicated in controlling mitochondrial
Aleix Prat et al.
Breast cancer research and treatment, 147(1), 185-191 (2014-07-23)
BRCA1-mutated breast cancer is associated with basal-like disease; however, it is currently unclear if the presence of a BRCA1 mutation depicts a different entity within this subgroup. In this study, we compared the molecular features among basal-like tumors with and
Daniel Tondera et al.
The Journal of biological chemistry, 279(30), 31544-31555 (2004-05-25)
We identified a novel human cDNA encoding a mitochondrial protein, MTP18 (mitochondrial protein, 18 kDa) as a transcriptional downstream target of phosphatidylinositol (PI) 3-kinase signaling. We demonstrate that MTP18 mRNA as well as protein expression is dependent on PI 3-kinase
Arne Jahn et al.
EMBO reports, 18(6), 929-946 (2017-05-14)
Telomeres constitute the ends of linear chromosomes and together with the shelterin complex form a structure essential for genome maintenance and stability. In addition to the constitutive binding of the shelterin complex, other direct, yet more transient interactions are mediated
Mitochondrial protein 18 is a positive apoptotic regulator in cardiomyocytes under oxidative stress.
Lynn H H Aung et al.
Clinical science (London, England : 1979), 133(9), 1067-1084 (2019-04-25)
Accumulation of reactive oxygen species is a common phenomenon in cardiac stress conditions, for instance, coronary artery disease, aging-related cardiovascular abnormalities, and exposure to cardiac stressors such as hydrogen peroxide (H2O2). Mitochondrial protein 18 (Mtp18) is a novel mitochondrial inner
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