SAB4500823
抗-PAR1（裂解-Ser42），N-端 兔抗
affinity isolated antibody
别名:
CXCR-7, CXCR7, G蛋白偶联受体159, G蛋白偶联受体RDC1, 趋化因子孤儿受体1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
western blot
western blot
Species reactivity:
human
Citations:
9
Technique(s):
ELISA: 1:20000
western blot: 1:500-1:1000
western blot: 1:500-1:1000
Uniprot accession no.:
产品名称
抗-PAR1（裂解-Ser42），N-端 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 46 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
proteolytically cleaved (Ser42)
Quality Level
Gene Information
human ... F2R(2149)
Application
兔抗PAR1（裂解-Ser42）N末端抗体可用于蛋白质印迹分析。
Biochem/physiol Actions
蛋白酶激活受体1（PAR1）促进血管生成并影响肿瘤生长和疾病进展的过程。此外，它在炎症和血栓形成中也起着至关重要的作用。该基因的突变与肾细胞癌转移风险增加和预后较差有关。已经在各种类型的癌症中观察到该基因的表达升高，例如卵巢癌，乳腺癌，肺癌，前列腺癌和黑色素瘤。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用，我们将全额退款或安排替代抗体。了解更多信息。
General description
抗-PAR1（裂解-Ser42）抗体可检测内源水平的活化PAR1（裂解-Ser42）蛋白片段。
蛋白酶活化受体-1（PAR1），也称为凝血因子II凝血酶受体（F2R），由定位于人染色体5q13.3的基因编码。编码的蛋白是细胞表面七跨膜G蛋白偶联受体。
蛋白酶活化受体-1（PAR1），也称为凝血因子II凝血酶受体（F2R），由定位于人染色体5q13.3的基因编码。编码的蛋白是细胞表面七跨膜G蛋白偶联受体。
Immunogen
该抗血清是针对衍生自人PAR1的合成肽而生成的。
免疫原范围： 23-72
免疫原范围： 23-72
Physical form
兔IgG，溶于磷酸盐缓冲液（不含Mg2+和Ca2+），pH 7.4,150mM NaCl，0.02％叠氮化钠和50％甘油中。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Uncoupling of the profibrotic and hemostatic effects of thrombin in lung fibrosis.
Shea B S, et al.
JCI insight, 2(9) (2017)
Barry S Shea et al.
JCI insight, 2(9) (2017-05-05)
Fibrotic lung disease, most notably idiopathic pulmonary fibrosis (IPF), is thought to result from aberrant wound-healing responses to repetitive lung injury. Increased vascular permeability is a cardinal response to tissue injury, but whether it is mechanistically linked to lung fibrosis
Zhuang-Zhuang Tang et al.
Naunyn-Schmiedeberg's archives of pharmacology (2021-11-19)
Upregulation of thrombin receptor protease-activated receptor 1 (PAR-1) is verified to contribute to chronic kidney diseases, including diabetic nephropathy; however, the mechanisms are still unclear. In this study, we investigated the effect of PAR-1 on high glucose-induced proliferation of human
Potential importance of protease activated receptor (PAR)-1 expression in the tumor stroma of non-small-cell lung cancer.
Lin C, et al.
BMC Cancer, 17(1), 113-113 (2017)
A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization.
Swift S, et al.
The Journal of Biological Chemistry, 285(15), 11402-11410 (2010)
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