SAB4501309
抗-GR 兔抗
affinity isolated antibody
别名:
GCR, GRL, GRL1, NR3C1, 糖皮质激素受体
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, IHC, WB
Species reactivity:
rat, mouse, human
Citations:
13
Technique(s):
ELISA: 1:40000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
Uniprot accession no.:
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 85 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NR3C1(2908)
Application
抗-GR抗体已用于蛋白质印迹。
Biochem/physiol Actions
糖皮质激素受体（GR）基因/（NR3C1）与哮喘有关。它是葡萄糖稳态、高胰岛素血症和脂肪沉积增加所必需的。它还调节细胞分化、神经和免疫系统功能。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用，我们将全额退款或安排替代抗体。了解更多信息。
General description
糖皮质激素受体（GR）基因/NR3C1（核受体亚家族3组C成员1）位于人染色体5q31。属于类固醇受体超家族，由配体激活的核转录因子组成。
Immunogen
该抗血清是针对衍生自人GR的合成肽而生成的。
免疫原范围： 181-230
免疫原范围： 181-230
Physical form
兔IgG，溶于磷酸盐缓冲液（不含Mg2+和Ca2+），pH 7.4,150mM NaCl，0.02％叠氮化钠和50％甘油中。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Ken Kobayashi et al.
Toxicology in vitro : an international journal published in association with BIBRA, 63, 104741-104741 (2019-11-30)
Nicotine from tobacco smoke is absorbed into the bloodstream and transferred into breast milk in breastfeeding mothers. Smoking causes a decrease in breast milk volume, adverse changes to the milk composition, and a shortened lactation period. Breast milk is produced
Yalan Deng et al.
Nature communications, 12(1), 7041-7041 (2021-12-08)
Despite unprecedented responses of some cancers to immune checkpoint blockade (ICB) therapies, the application of checkpoint inhibitors in pancreatic cancer has been unsuccessful. Glucocorticoids and glucocorticoid receptor (GR) signaling are long thought to suppress immunity by acting on immune cells.
Prolactin and glucocorticoid signaling induces lactation-specific tight junctions concurrent with ?-casein expression in mammary epithelial cells
Kobayashi K, et al.
Biochimica et Biophysica Acta, 1863(8), 2006-2016 (2016)
Fulu Ai et al.
Oncology reports, 43(2), 427-436 (2020-01-03)
Glucocorticoids (GCs) are known potent clinical drugs, however, their mode of action is still complex and debatable. Macrophages are the most important target of GCs and play a key role in tumor immunity in vivo, but their relationship is also controversial. In
Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids
Breslin MB, et al.
Molecular Endocrinology, 15(8), 1381-1395 (2001)
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