产品名称
Anti-MYC antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 48 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MYC(4609)
Application
Anti-MYC antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
MYC proto-oncogene, bHLH transcription factor (MYC) is known to induce tumor growth in a variety of cancer types. c-MYC overexpression promotes DNA replication, transcription, translation and metabolism in cancer cells. Upregulation of this gene is observed in pancreatic ductal adenocarcinoma and diffuse large B-cell lymphoma (DLBCL).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
The MYC (MYC proto-oncogene, bHLH transcription factor) gene is mapped to human chromosome 8q24.21. This gene encodes an oncogenic transcription factor and belongs to the MYC gene family. Anti-MYC antibody detects endogenous levels of total MYC protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human MYC.
Immunogen Range: 386-435
Immunogen Range: 386-435
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Knockdown of ASF1B inhibits cell proliferation, migration, invasion and cisplatin resistance in gastric cancer through the Myc pathway.
Zhang, et al.
Oncology Letters, 25, 242-242 (2023)
c-MYC amplification and c-myc protein expression in pancreatic acinar cell carcinomas. New insights into the molecular signature of these rare cancers
La RS, et al.
Virchows Archiv, 9(5), 1-7 (2018)
PVT1 dependence in cancer with MYC copy-number increase
Tseng YY, et al.
Nature, 512(7512), 82-82 (2014)
Checkpoint suppressor 1 suppresses transcriptional activity of ERalpha and breast cancer cell proliferation via deacetylase SIRT1
Xu, Z, et al.
Cell Death & Disease, 9(5), 559-559 (2018)
Zhaowei Xu et al.
Cell death & disease, 9(5), 559-559 (2018-05-13)
Breast cancer is a highly heterogeneous carcinoma in women worldwide, but the underlying mechanisms that account for breast cancer initiation and development have not been fully established. Mounting evidence indicates that Checkpoint suppressor 1 (CHES1) is tightly associated with tumorigenesis
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