Anti-NNOS antibody produced in rabbit

Anti-NNOS antibody detects endogenous levels of total NNOS protein.

The NNOS (nitric oxide synthase 1) gene is mapped to human chromosome 12q24.22. Neuronal nitric oxide synthase is known to be expressed in skeletal muscles, the heart and the brain.

The antiserum was produced against synthesized peptide derived from human nNOS.

Immunogen Range: 818-867

Anti-NNOS antibody produced in rabbit has been used in immunohistochemistry.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

NNOS (nitric oxide synthase 1) is responsible for the synthesis of NO (nitric oxide) as well as superoxide. Stress induces the activity of NNOS and generation of NO and results in the formation of nitrogen radicals. Elevation of nitrogen radical leads to intracellular protein damage and also induces impairment to mitochondrial transport chain components. This generally results in cellular energy deficiency. NNOS is known to regulate vasodilation in the forearm, in response to stress. Neuronal nitric oxide synthase normally functions to control the basal coronary blood flow.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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