产品名称
抗-CAMK2 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 54 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CAMK2A(815)
Biochem/physiol Actions
钙/钙调素依赖性蛋白激酶IIα(CAMK2)对于长时程增强(LTP)和空间记忆十分重要。可调节突触可塑性。其基因异常与精神分裂症、癫痫和自闭症谱系障碍有关。
钙调素依赖性蛋白激酶II复合体δ(CAMK2D)可调节离子通道和Ca2+调节蛋白的功能。还可调节组蛋白的磷酸化和乙酰化。已证明它在糖尿病人心肌中过表达。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
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General description
抗CAMK2抗体可用于检测CAMK2蛋白的内源性总水平。
钙/钙调素依赖性蛋白激酶IIα(CAMK2)是一种钙激活的丝氨酸/苏氨酸激酶。其基因位于人染色体5q32上。CAMK2主要表达于中枢神经系统。由一个激酶功能域、一个调节功能域和一个聚合功能域组成。
Immunogen
针对人CaMK2 α/δ来源合成肽生产的抗血清。
免疫原范围： 256-305
免疫原范围： 256-305
Physical form
兔IgG，溶于磷酸盐缓冲液（不含Mg2+和Ca2+），pH 7.4,150mM NaCl，0.02％叠氮化钠和50％甘油中。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Osiris Germán Idelfonso-García et al.
Antioxidants (Basel, Switzerland), 13(3) (2024-03-28)
Aging is characterized by increased reactive species, leading to redox imbalance, oxidative damage, and senescence. The adverse effects of alcohol consumption potentiate aging-associated alterations, promoting several diseases, including liver diseases. Nucleoredoxin (NXN) is a redox-sensitive enzyme that targets reactive oxygen
Targeted multiplexed selected reaction monitoring analysis evaluates protein expression changes of molecular risk factors for major psychiatric disorders
Wesseling H, et al.
The International Journal of Neuropsychopharmacology, 18(1) (2015)
De novo variants in CAMK 2A and CAMK 2B cause neurodevelopmental disorders
Akita T, et al.
Annals of Clinical and Translational Neurology, 5(3), 280-296 (2018)
A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability
Chia PH, et al.
eLife, 7, e32451-e32451 (2018)
Matilda K Dahlqvist et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 40(10), 2010-2025 (2019-10-28)
Gamma activity arising from the interplay between pyramidal neurons and fast-spiking parvalbumin (PV) interneurons is an integral part of higher cognitive functions and is assumed to contribute significantly to brain metabolic responses. Cerebral metabolic rate of oxygen (CMRO2) responses were
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