产品名称
Anti-phospho-TIP60 (pSer86) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 58 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer86)
Quality Level
Gene Information
human ... KAT5(10524)
Application
TIP60 (HIV1-TATinteractive protein) possess acetyltransferase activity and participates in chromatin remodeling and DNA damage repair. TIP60 is involved in protein stabilization and protein function modulation. The presence of chromodomain and MYST domain in its structure enables acetylation of both histone and non-histone proteins. TIP60 in association with androgenic receptors and transcription factors can control gene transcription and cell cycle process. TIP60 mediates p53 action to induce apoptosis. TIP60 inhibits Hepatitis B virus infection. TIP60 acts as a haploinsufficient tumor suppressor.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
The TIP60 (HIV1 (human immunodeficiency virus 1)-TAT interactive protein) gene is mapped to human chromosome 11q13.1. It is ubiquitously expressed and evolutionarily conserved. The encoded protein, Tip60 belongs to the MYST (Moz, Ybf2/Sas3, Sas2 and TIP60) family.
Immunogen
The antiserum was produced against synthesized peptide derived from human TIP60 around the phosphorylation site of Ser86.
Immunogen Range: 52-101
Immunogen Range: 52-101
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Cellular functions of TIP60
Sapountzi V, et al.
The International Journal of Biochemistry & Cell Biology, 38(9), 1496-1509 (2006)
TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter
Rajagopalan D, et al.
PLoS Pathogens, 13(10), e1006681-e1006681 (2017)
TIP60 complex inhibits HBV transcription
Nishitsuji H, et al.
Journal of Virology, JVI-01788 (2018)
Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell
Ashraf W, et al.
Journal of Experimental & Clinical Cancer Research, 36(1), 188-188 (2017)
Marcella M Authiat et al.
Neural plasticity, 2022, 3172861-3172861 (2022-03-04)
Recently, we showed that DNA double-strand breaks (DSBs) are increased by the Aβ 42-amyloid peptide and decreased by all-trans retinoic acid (RA) in SH-SY5Y cells and C57BL/6J mice. The present work was aimed at investigating DSBs in cells and murine
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