产品名称
Anti-phospho-CXCR4 (pSer339) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 39 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer339)
Quality Level
Gene Information
human ... CXCR4(7852)
Application
Anti-phospho-CXCR4 (pSer339) antibody has been used in immunohistochemical analysis.
Biochem/physiol Actions
The CXC chemokine receptor 4 (CXCR4) participates in the progression of the embryo, immune and inflammatory responses, modulation of hematopoiesis, human immunodeficiency virus infection and stimulation of angiogenesis. CXCR4 and its ligand, CXCL12 is involved in the synthesis of B-cell, myelopoiesis, integrin activation and chemotaxis.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
The CXC chemokine receptor 4 (CXCR4) is a G-protein coupled 7-transmembrane (TM) chemokine receptor. It is made up of 352 amino acids. CXCR4 is expressed on the surface of T-cells, B-cells, monocytes, neutrophils and dendritic cells. This gene is located on human chromosome 2q22.1.
Immunogen
The antiserum was produced against synthesized peptide derived from human CXCR4 around the phosphorylation site of Ser339.
Immunogen Range: 303-352
Immunogen Range: 303-352
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons.
Yang S, et al.
Development, dev-098145 (2013)
The prognostic value of C-X-C motif chemokine receptor 4 in patients with sporadic malignant peripheral nerve sheath tumors.
Chao Z, et al.
Chinese Journal of Cancer, 36(1), 80-80 (2017)
The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential.
Peng D, et al.
European Journal of Medicinal Chemistry, 149, 148-169 (2018)
Shanzheng Yang et al.
Development (Cambridge, England), 140(22), 4554-4564 (2013-10-25)
CXCL12/CXCR4 signaling has been reported to regulate three essential processes for the establishment of neural networks in different neuronal systems: neuronal migration, cell positioning and axon wiring. However, it is not known whether it regulates the development of A9-A10 tyrosine
Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility.
Finkel T H, et al.
BMC Medical Genetics, 17(1), 24-24 (2016)
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