Anti-phospho-PLK1 (pSer¹³⁷) antibody produced in rabbit

Polo-like kinase 1 (PLK1) belongs to the polo-like kinase family. PLK1 is characterized with two COOH-terminal polo box domain and N-terminal kinase domain involved in drug development. PLK1 is expressed primarily at centrosomes and at the midbody of dividing cells.

The antiserum was produced against synthesized peptide derived from human PLK1 around the phosphorylation site of Ser137.

Immunogen Range: 103-152

Polo-like kinase 1 (PLK1) is involved in regulation of mitosis. PLK1 plays a crucial role in centrosome-mediated microtubule events and spindle assembly. PLK1 expression is elevated in cancer tissues. Thus, it can be used as a potential prognostic marker for several cancers, including non-small-cell lung cancer, squamous-cell carcinomas of the head and neck, melanomas, colorectal cancer, oropharyngeal carcinomas, and ovarian and endometrial carcinomas. PLK1 recruited to centrosomes during S-phase by centrosomal protein FOP-related protein of 20kDa (FOR20), plays a vital role in S-phase progression. The protein also plays an essential role in central spindle formation and cytokinesis. PLK1 inhibitors might act as a potential therapeutics in cancer treatment.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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