biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 68 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer137)
Gene Information
human ... PLK1(5347)
General description
Polo-like kinase 1 (PLK1) belongs to the polo-like kinase family. PLK1 is characterized with two COOH-terminal polo box domain and N-terminal kinase domain involved in drug development. PLK1 is expressed primarily at centrosomes and at the midbody of dividing cells.
Immunogen
The antiserum was produced against synthesized peptide derived from human PLK1 around the phosphorylation site of Ser137.
Immunogen Range: 103-152
Immunogen Range: 103-152
Biochem/physiol Actions
Polo-like kinase 1 (PLK1) is involved in regulation of mitosis. PLK1 plays a crucial role in centrosome-mediated microtubule events and spindle assembly. PLK1 expression is elevated in cancer tissues. Thus, it can be used as a potential prognostic marker for several cancers, including non-small-cell lung cancer, squamous-cell carcinomas of the head and neck, melanomas, colorectal cancer, oropharyngeal carcinomas, and ovarian and endometrial carcinomas. PLK1 recruited to centrosomes during S-phase by centrosomal protein FOP-related protein of 20kDa (FOR20), plays a vital role in S-phase progression. The protein also plays an essential role in central spindle formation and cytokinesis. PLK1 inhibitors might act as a potential therapeutics in cancer treatment.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Minhong Shen et al.
Cell research, 23(11), 1284-1295 (2013-09-11)
Centrosomes are required for efficient cell cycle progression mainly by orchestrating microtubule dynamics and facilitating G1/S and G2/M transitions. However, the role of centrosomes in S-phase progression is largely unknown. Here, we report that depletion of FOR20 (FOP-related protein of
Takao Takahashi et al.
Cancer science, 94(2), 148-152 (2003-04-24)
PLK (polo-like kinase), the human counterpart of polo in Drosophila melanogaster and of CDC5 in Saccharomyces cerevisiae, belongs to a family of serine/threonine kinases. It is intimately involved in spindle formation and chromosome segregation during mitosis. The purpose of this
Klaus Strebhardt et al.
Nature reviews. Cancer, 6(4), 321-330 (2006-03-25)
Human polo-like kinase 1 (PLK1) is essential during mitosis and in the maintenance of genomic stability. PLK1 is overexpressed in human tumours and has prognostic potential in cancer, indicating its involvement in carcinogenesis and its potential as a therapeutic target.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB4504640-100UG | 04061832527208 |