产品名称
单克隆抗-CD63 小鼠抗, clone MEM-259, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
MEM-259, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
1 mg/mL
technique(s)
flow cytometry: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CD63(967)
Application
小鼠中生产的抗CD63单克隆抗体已被用于流式细胞仪和共聚焦成像中。
该试剂是为流式细胞分析而设计的。流式细胞仪的建议工作稀释度为2 μg/mL的样品。这里的稀释度是使用本产品的推荐起点。工作浓度应由研究者确定。
Biochem/physiol Actions
分化簇 63(CD63)是血小板活化的标志物之一,在体外血小板聚集、胶原蛋白附着、氧化低密度脂蛋白(LDL)的摄取以及血管生成的调节中起关键作用。CD63 的表达不足导致常染色体隐性遗传病Hermansky-Pudlak 综合征。CD63 与各种细胞功能有关,如细胞粘附、细胞分化、迁移、癌症发生、肿瘤进展。CD63在梅克尔细胞癌(Merkel cell carcinoma)的初期高度表达,在较晚期表达下降;因此,CD63被认为是这种癌症的潜在预后因子。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
您可完全放心的评估我们的抗体。如果抗体在您的应用中没有发挥效果,我们将给予您完全的赔偿或更换抗体。 了解更多。
General description
分化簇 63(CD63),也称为黑色素瘤1抗原,由定位于人类染色体12q13.2的基因编码。编码的蛋白属于跨膜4超家族(TM4SF)。CD63是一种整合膜糖蛋白,在晚期的内吞体和溶酶体中表达,也存在于血小板致密颗粒膜。
抗体MEM-259可与CD63(LAMP-3)反应,CD63是一种40-60 kDa的四跨膜糖蛋白,由粒细胞、血小板、T细胞、单核细胞/巨噬细胞和内皮细胞表达。CD63的细胞表面暴露通常依赖于其激活。
Immunogen
HPB-ALL T细胞系
Physical form
溶于磷酸盐缓冲盐水,pH 7.4,含有15 mM 叠氮化钠。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
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