SAB5201266
单克隆抗Pink1 小鼠抗
clone S4-15, purified immunoglobulin
别名:
抗-PTEN-诱导的假定激酶蛋白1, 抗 BRPK, 抗帕金森病（常染色体隐性遗传）6
登录 查看组织和合同定价。
选择尺寸
关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
S4-15, monoclonal
Application:
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
rat, mouse, human
Citations:
3
Technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
immunohistochemistry: suitable
western blot: suitable
Uniprot accession no.:
产品名称
单克隆抗Pink1 小鼠抗, clone S4-15, purified immunoglobulin
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
S4-15, monoclonal
form
buffered aqueous solution
mol wt
antigen predicted mol wt 50 kDa
species reactivity
rat, mouse, human
concentration
1 mg/mL
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PINK1(65018)
Biochem/physiol Actions
PTEN诱导的激酶1 (PINK1)参与线粒体组分的生物发生。它介导线粒体呼吸链编码核mRNA亚基的翻译。PINK1基因的激酶结构域区域包含了大部分的突变。PINK1基因突变与早发性帕金森病(PD)有关。在功能失调的线粒体中，PINK1的积累标志着它们的降解。PINK1也与癌症、糖尿病和肺纤维化的病理生理学有关。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
Features and Benefits
完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用，我们将全额退款或安排替代抗体。了解更多信息。
General description
PTEN诱导的激酶1（PINK1）是定位到线粒体的丝氨酸/苏氨酸激酶。它包括线粒体N端靶向序列、C端激酶结构域和跨膜锚定区。PINK1基因定位于人类染色体1p36.12。
Immunogen
人PINK1的融合蛋白氨基酸112-496（胞质C-端）。82%与大鼠相同，81%与小鼠相同。>30%与DMPK一致。
Physical form
PBS pH 7.4，50%甘油，0.1%叠氮化钠
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Mutation Analysis of Consanguineous Moroccan Patients with Parkinson's Disease Combining Microarray and Gene Panel.
Bouhouche, et al.
Frontiers in Neurology, 8, 567-567 (2020)
Francesco Brunelli et al.
Mechanisms of ageing and development, 189, 111277-111277 (2020-06-07)
Extensive studies on PINK1, whose mutations are a confirmed cause of Parkinson's disease (PD), have been conducted in animal models or immortalized cell lines. These include initial ground-breaking discoveries on mitophagy, which demonstrated that PINK1 recruits Parkin on depolarized mitochondria
Alicia M Pickrell et al.
Neuron, 85(2), 257-273 (2015-01-23)
Understanding the function of genes mutated in hereditary forms of Parkinson's disease yields insight into disease etiology and reveals new pathways in cell biology. Although mutations or variants in many genes increase the susceptibility to Parkinson's disease, only a handful
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持