一般描述
The RET (rearranged during transfection) proto-oncogene is mapped to human chromosome 10q11. It has two isoforms, namely RET9 and RET51 with unique C-terminal tail sequences. RET is made of 20 exons and 21 introns.
免疫原
Purified recombinant fragment of RET (aa896-1063) expressed in E.coli.
Mouse monoclonal antibody raised against RET
Mouse monoclonal antibody raised against RET
生化/生理作用
The RET (rearranged during transfection) is involved in signal transduction pathways related to cell proliferation and differentiation. Mutations in RET gene results in medullary thyroid carcinoma and Hirschsprung′s disease. It is involved in normal development and cancer. The isoforms of RET provides distinct protein complexes to promote signals.
外形
Ascitic fluid containing 0.03% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Associations between RET tagSNPs and their haplotypes and susceptibility, clinical severity, and thyroid function in patients with differentiated thyroid cancer.
He C, et al.
PLoS ONE, 12(11), e0187968-e0187968 (2017)
Differential recruitment of E3-ubiquitin ligase complexes regulates RET isoform internalization.
Hyndman BD, et al.
Journal of Cell Science, 130(19), 3282-3296 (2017)
Rui-Xue Huang et al.
International journal of clinical and experimental pathology, 8(5), 5793-5797 (2015-07-21)
The purpose of the study is to investigate the relationship between rs1799939, rs1800858 and rs74799832 polymorphisms of RET with thyroid cancer (TC) susceptibility. Genotypes distribution of control groups were tested by Hardy-Weinberg equilibrium (HWE). Rs1799939, rs1800858 and rs74799832 polymorphisms of
Marjan Zarif Yeganeh et al.
Asian Pacific journal of cancer prevention : APJCP, 16(6), 2107-2117 (2015-04-01)
Thyroid cancer is the most common endocrine neoplasia. The medullary thyroid carcinoma (MTC) is one of the most aggressive forms of thyroid malignancy,accounting for up to 10% of all types of this disease. The mode of inheritance of MTC is
C Tomuschat et al.
Pediatric surgery international, 31(8), 701-710 (2015-07-15)
During the past two decades several genes have been identified that control morphogenesis and differentiation of the enteric neuron system (ENS). These genes, when mutated or deleted, interfere with ENS development. RET gene is the major gene causing Hirschsprung's disease
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