产品名称
假尿苷, ≥98% (HPLC)
SMILES string
[nH]1[c]([nH]cc([c]1=O)[C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=O
InChI
1S/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1
InChI key
PTJWIQPHWPFNBW-GBNDHIKLSA-N
biological source
synthetic (chemical)
assay
≥98% (HPLC)
form
powder
mol wt
244.2
color
white to off-white
mp
222 °C ((432 °F ))
solubility
water: soluble
storage temp.
2-8°C
Quality Level
Application
伪尿嘧啶是一种用途广泛的化合物和生物标志物，可用于代谢组学和生化研究。
Features and Benefits
- 高纯度化合物适用于各种研究应用
General description
伪尿苷是一种C-糖基嘧啶，由尿嘧啶组成，尿嘧啶在位置5处连接有β-D-呋喃呋喃糖基残基。嘧啶核苷尿苷的C-糖基异构体。它具有基本代谢物的作用。假尿苷存在于除mRNA以外的所有物种和所有类别的RNA中。它由称为假尿苷合酶的酶形成，该酶在转录后异构化RNA中的特定尿苷残基。
假尿嘧啶(Ψ)是核苷尿嘧啶的同分异构体，具有碳-碳键而不是典型的连接尿嘧啶的氮-碳糖苷键。它代表了RNA内无数修饰核苷中最普遍的形态，存在于各种物种和RNA类别中。Ψ合成酶的酶促作用诱导特定尿嘧啶残基的转录后异构化，这一过程被称为假尿嘧啶化。这种修饰，特别是在rRNA和tRNA中，在微调和稳定区域结构中起着至关重要的作用，有助于mRNA解码、核糖体组装、加工和转译功能。此外，在细菌、古细菌和真核生物的tRNA中发现的β-假尿嘧啶已被证明具有减少人类淋巴细胞中辐射诱导的染色体畸变的潜力。它作为癌症和增殖生物标志物的效用使其成为代谢组学和生化研究的宝贵资产。
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Sang-Hoon Kim et al.
Nucleic acids research, 49(1), 491-503 (2020-12-09)
RNA modifications can regulate the stability of RNAs, mRNA-protein interactions, and translation efficiency. Pseudouridine is a prevalent RNA modification, and its metabolic fate after RNA turnover was recently characterized in eukaryotes, in the plant Arabidopsis thaliana. Here, we present structural
Fiona Maiyo et al.
Pharmaceuticals (Basel, Switzerland), 12(4) (2019-11-07)
Systemic messenger RNA (mRNA) delivery, although still in its infancy, holds immense potential for application in cancer vaccination and immunotherapy. Its advantages over DNA transfection make it attractive in applications where transient expression is desired. However, this has proved challenging
Justin M Waldern et al.
Mobile DNA, 12(1), 9-9 (2021-03-09)
Group II introns are mobile retroelements, capable of invading new sites in DNA. They are self-splicing ribozymes that complex with an intron-encoded protein to form a ribonucleoprotein that targets DNA after splicing. These molecules can invade DNA site-specifically, through a
Hanieh Moradian et al.
Journal of molecular medicine (Berlin, Germany), 98(12), 1767-1779 (2020-11-05)
Advanced non-viral gene delivery experiments often require co-delivery of multiple nucleic acids. Therefore, the availability of reliable and robust co-transfection methods and defined selection criteria for their use in, e.g., expression of multimeric proteins or mixed RNA/DNA delivery is of
Glynis Klinke et al.
Journal of inherited metabolic disease, 43(4), 712-725 (2020-01-14)
Laboratory investigations of cerebrospinal fluid (CSF) are essential when suspecting an inborn error of metabolism (IEM) involving neurological features. Available tests are currently performed on different analytical platforms, requiring a large sample volume and long turnaround time, which often delays
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