SML0016
CCG-63802
别名:
α-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
DMSO: ≥5 mg/mL (;warmed DMSO)
storage temp.
room temp
Quality Level
Application
CCG-63802 may be used to study G-protein-mediated cell signaling.
Biochem/physiol Actions
CCG-63802 is a reversible, allosteric inhibitor of RGS4
GCC-63802 binds to RGS4 and blocks interaction with Goa (IC50 = 1.9 uM). RGS4 (Regulator of G protein Signaling) is one of the RGP proteins responsible for terminating mu opioid receptor signaling. RSG proteins are GTPase activators, and drive G protein subunits to an inactive, GDP-bound form.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the G Proteins (Heterotrimeric) and Opioid Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
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商品
Heterotrimeric G proteins modulate intracellular signals from 7TM receptors, impacting various cellular functions and drug targets.
We offers many products related to opioid receptors for your research needs.
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
由α，β和γ亚基所组成的异源三聚体G蛋白通过调节细胞内效应蛋白如酶和离子通道，可对由活化的七跨膜（7TM）受体产生的细胞外信号产生响应。
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