SML0153
栀子苷
≥98% (HPLC), iridoid glycoside, powder
别名:
（1S,4αS，7αS） -1-（β-D-吡喃葡萄糖氧基）-1，4a，5，7a-四氢-7-（羟甲基）-环戊[c]吡喃 -4-羧酸甲酯
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关于此项目
经验公式（希尔记法）:
C17H24O10
化学文摘社编号:
分子量:
388.37
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
栀子苷, ≥98% (HPLC)
SMILES string
COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]3[C@@H]1CC=C3CO
InChI
1S/C17H24O10/c1-24-15(23)9-6-25-16(11-7(4-18)2-3-8(9)11)27-17-14(22)13(21)12(20)10(5-19)26-17/h2,6,8,10-14,16-22H,3-5H2,1H3/t8-,10-,11-,12-,13+,14-,16+,17+/m1/s1
InChI key
IBFYXTRXDNAPMM-BVTMAQQCSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: ≥5 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
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Biochem/physiol Actions
栀子苷是一种具有抗氧化和其他生物活性的环烯醚萜苷。
栀子苷是一种环烯醚萜苷，具有多种生物活性，包括神经保护、抗糖尿病、抗增殖和抗氧化活性。研究表明，栀子苷可调节 Nrf2 转运，并通过 PI3K/Akt 信号通路上调下游抗氧化蛋白 HO-1 的表达，这可能是其神经保护和抗氧化活性的机制。胰高血糖素样肽 1（GLP-1）受体也可能在栀子苷诱导的 HO-1 表达中起关键作用。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Min Zhou et al.
Fitoterapia, 83(8), 1558-1561 (2012-09-15)
Geniposide was prepared on a large-scale using a selective two-phase liquid-liquid extraction. The aqueous residue from the fruit of Gardenia jasminoides Ellis was treated with sodium carbonate and extracted with n-butanol several times. The n-butanol extracts were treated with activated
Jianhui Liu et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(7), 1093-1097 (2012-07-24)
β-Cell apoptosis is considered to be a major cause of loss of β cells in diabetes. Geniposide could prevent oxidative stress-induced neuron apoptosis, and improved glucose stimulated insulin secretion by activating glucagon-like peptide 1 receptor (GLP-1R) in INS-1 cells. Here
Gu Zhang et al.
International journal of molecular medicine, 30(3), 561-568 (2012-06-20)
Activated microglia producing reactive nitrogen species, inflammatory factors, reactive oxygen species (ROS) and other neurovirulent factors, can lead to the development of neurodegenerative diseases. Certain compounds can inhibit the activation of microglia. However, the mechanisms remain unclear. In the present
K Hiramatsu et al.
Alimentary pharmacology & therapeutics, 36(6), 575-586 (2012-07-24)
Idiopathic mesenteric phlebosclerosis (IMP) is a rare disease, characterised by thickening of the wall of the right hemicolon with calcification of mesenteric veins. However, the aetiology remains unknown. To investigate the possible association of herbal medicines with IMP. The clinical
Jinhong Liu et al.
Aging, 12(22), 22744-22758 (2020-11-17)
Acute kidney injury is one of the most common complications that occurs in septic shock. An effective therapeutic intervention is urgently needed. Geniposide has been reported to possess pleiotropic activities against different diseases. However, the effect of geniposide on sepsis-induced
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