SML0180
乙酰甲啶 盐酸盐
≥98% (HPLC)
别名:
1-Azabicyclo[2.2.2]oct-3-yl acetate hydrochloride, 3-Acetoxyquinuclidine hydrochloride
产品名称
乙酰甲啶 盐酸盐, ≥98% (HPLC)
InChI key
LWWSARSTZGNKGV-FVGYRXGTSA-N
InChI
1S/C9H15NO2.ClH/c1-7(11)12-9-6-10-4-2-8(9)3-5-10;/h8-9H,2-6H2,1H3;1H/t9-;/m0./s1
SMILES string
Cl.CC(=O)O[C@H]1CN2CC[C@H]1CC2
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
solubility
H2O: ≥15 mg/mL at ~60 °C
storage temp.
−20°C
Quality Level
相关类别
Application
Aceclidine hydrochloride may be used in muscarinic acetylcholine receptor-mediated cell signaling studies.
Biochem/physiol Actions
Aceclidine at a concentration of 5 and 50 μg is capable of enhancing the outflow facility, following ciliary muscle disinsertion.
Aceclidine hydrochloride is a parasympathomimetic drug with weak anticholinesterase activity. It acts on cholinergic nerve-endings, lowers intraocular pressure and potent therapeutic agent for open-angle glaucoma.
Aceclidine is a non-selective muscarinic acetylcholine receptor partial agonist that is effective in reducing intraocular pressure.
Muscarinic receptor partial agonist
Features and Benefits
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Double-blind cross-over comparison of aceclidine and pilocarpine in open-angle glaucoma.
J H Romano
The British journal of ophthalmology, 54(8), 510-521 (1970-08-01)
Aceclidine effects on outflow facility after ciliary muscle disinsertion
Hubbard WC, et al.
Ophthalmologica, 210(5), 303-307 (1996)
商品
Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.
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