SML0462
Alda-1
≥98% (HPLC)
别名:
N-（1,3-苯并二氧戊环-5-基甲基）-2,6-二氯苯甲酰胺
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关于此项目
经验公式（希尔记法）:
C15H11Cl2NO3
化学文摘社编号:
分子量:
324.16
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
Alda-1, ≥98% (HPLC)
InChI
1S/C15H11Cl2NO3/c16-10-2-1-3-11(17)14(10)15(19)18-7-9-4-5-12-13(6-9)21-8-20-12/h1-6H,7-8H2,(H,18,19)
SMILES string
Clc1cccc(Cl)c1C(=O)NCc2ccc3OCOc3c2
InChI key
NMKJFZCBCIUYHI-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL (clear solution)
storage temp.
2-8°C
Quality Level
相关类别
Application
Alda-1 已作为醛脱氢酶 2 (ALDH2) 的激动剂被用于：
- 研究其对 H2O2-诱导的小鼠跟腱病中跟腱细胞的冷冻保护作用
- 研究其对 ALDH2 基因敲除小鼠中酒精衍生 DNA 损伤的保护作用
- 研究其对小鼠皮肤伤口愈合的影响
Biochem/physiol Actions
Alda-1 可减轻氧化应激对多种人体细胞（如肺内皮细胞、脐静脉内皮细胞和肝细胞）造成的损伤。
Alda-1 是 ALDH2 激动剂；野生型 ALDH2*1 和亚洲 E487K 突变体 ALDH2*2 形式的线粒体醛脱氢酶 2 的细胞可透过性激活剂。
Alda-1 是 ALDH2 激动剂；野生型 ALDH2*1 和亚洲 E487K 突变体 ALDH2*2 形式的线粒体醛脱氢酶 2 的细胞可透过性激活剂。ALDH2 是氧化酶，其除去乙醇代谢物乙醛和其他脂肪醛。同时。 ALDH2 参与血管扩张剂硝酸甘油生物转化为一氧化氮的过程。Alda-1 通过 ALDH2*1（野生型）和 ALDH2*2（亚洲突变体）增加乙醛氧化，分别约 1.5 倍和 6 倍。似乎 Alda-1 通过增强 NAD 结合来刺激 ALDH2 的乙醛氧化，但不增强亚洲突变体的硝酸甘油结合亲和力。
存储类别
11 - Combustible Solids
wgk
WGK 3
Tingting Fang et al.
Molecular medicine reports, 18(3), 2807-2815 (2018-07-18)
The aim of the present study was to investigate whether necroptosis occurs in high glucose (HG)-induced H9c2 cardiac cell injury and whether the activation of aldehyde dehydrogenase 2 (ALDH2) can inhibit necroptosis. H9c2 cardiac cells were treated with 35 mM glucose
Gina D Kusuma et al.
Scientific reports, 7, 42397-42397 (2017-02-17)
High resistance to oxidative stress is a common feature of mesenchymal stem/stromal cells (MSC) and is associated with higher cell survival and ability to respond to oxidative damage. Aldehyde dehydrogenase (ALDH) activity is a candidate "universal" marker for stem cells.
Weiming Yan et al.
BMC ophthalmology, 20(1), 55-55 (2020-02-20)
Retinitis pigmentosa (RP) is a kind of inherited retinal degenerative diseases characterized by the progressive loss of photoreceptors. RP has been a conundrum without satisfactory countermeasures in clinic until now. Acetaldehyde dehydrogenase 2 (ALDH2), a major enzyme involved in aldehyde
Jianlu Guo et al.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 38(11), 1288-1293 (2018-12-06)
To investigate whether CaN-NFAT3 pathway mediates the protective effects of aldehyde dehydrogenase (ALDH) 2 in high glucose-treated neonatal rat ventricular myocytes. The ventricular myocytes were isolated from the heart of neonatal (within 3 days) SD rats by enzyme digestion and
Sahebgowda Sidramagowda Patil et al.
Frontiers in pharmacology, 11, 597942-597942 (2021-02-19)
Acute lung injury (ALI), a milder form of acute respiratory distress syndrome (ARDS), is a leading cause of mortality in older adults with an increasing prevalence. Oxygen therapy, is a common treatment for ALI, involving exposure to a high concentration
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