SML0462
Alda-1
≥98% (HPLC)
别名:
N-（1,3-苯并二氧戊环-5-基甲基）-2,6-二氯苯甲酰胺
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关于此项目
经验公式（希尔记法）:
C15H11Cl2NO3
化学文摘社编号:
分子量:
324.16
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 10 mg/mL (clear solution)
储存温度
2-8°C
SMILES字符串
Clc1cccc(Cl)c1C(=O)NCc2ccc3OCOc3c2
InChI
1S/C15H11Cl2NO3/c16-10-2-1-3-11(17)14(10)15(19)18-7-9-4-5-12-13(6-9)21-8-20-12/h1-6H,7-8H2,(H,18,19)
InChI key
NMKJFZCBCIUYHI-UHFFFAOYSA-N
相关类别
应用
Alda-1 已作为醛脱氢酶 2 (ALDH2) 的激动剂被用于：
- 研究其对 H2O2-诱导的小鼠跟腱病中跟腱细胞的冷冻保护作用
- 研究其对 ALDH2 基因敲除小鼠中酒精衍生 DNA 损伤的保护作用
- 研究其对小鼠皮肤伤口愈合的影响
生化/生理作用
Alda-1 可减轻氧化应激对多种人体细胞（如肺内皮细胞、脐静脉内皮细胞和肝细胞）造成的损伤。
Alda-1 是 ALDH2 激动剂；野生型 ALDH2*1 和亚洲 E487K 突变体 ALDH2*2 形式的线粒体醛脱氢酶 2 的细胞可透过性激活剂。
Alda-1 是 ALDH2 激动剂；野生型 ALDH2*1 和亚洲 E487K 突变体 ALDH2*2 形式的线粒体醛脱氢酶 2 的细胞可透过性激活剂。ALDH2 是氧化酶，其除去乙醇代谢物乙醛和其他脂肪醛。同时。 ALDH2 参与血管扩张剂硝酸甘油生物转化为一氧化氮的过程。Alda-1 通过 ALDH2*1（野生型）和 ALDH2*2（亚洲突变体）增加乙醛氧化，分别约 1.5 倍和 6 倍。似乎 Alda-1 通过增强 NAD 结合来刺激 ALDH2 的乙醛氧化，但不增强亚洲突变体的硝酸甘油结合亲和力。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Sahebgowda Sidramagowda Patil et al.
Frontiers in pharmacology, 11, 597942-597942 (2021-02-19)
Acute lung injury (ALI), a milder form of acute respiratory distress syndrome (ARDS), is a leading cause of mortality in older adults with an increasing prevalence. Oxygen therapy, is a common treatment for ALI, involving exposure to a high concentration
Che-Hong Chen et al.
EBioMedicine, 55, 102753-102753 (2020-05-14)
Aldehyde dehydrogenase 2 (ALDH2) catalyzes the detoxification of aliphatic aldehydes, including acetaldehyde. About 45% of Han Chinese (East Asians), accounting for 8% of humans, carry a single point mutation in ALDH2*2 (E504K) that leads to accumulation of toxic reactive aldehydes.
Qiankun Zhu et al.
Clinical science (London, England : 1979), 131(11), 1123-1136 (2017-03-23)
Many studies demonstrate that activation of aldehyde dehydrogenase 2 (ALDH2) protects against oxidative stress via detoxification of cytotoxic aldehydes, and could attenuate cardiac, cerebral, lung and renal ischaemia-reperfusion (I/R) injuries. However, the effect of ALDH2 in intestinal I/R is unknown. The
Fayez T Hammad et al.
Drug development research, 79(7), 315-323 (2018-10-07)
Renal ischemia-reperfusion injury (IRI) induces the production of aldehydes which are detoxified by aldehyde dehydrogenases (ALDHs). Alda-1 is a selective ALDH2 agonist and its protective effect was demonstrated in several conditions. The effect of Alda-1 on the kidney or on
Weiming Yan et al.
BMC ophthalmology, 20(1), 55-55 (2020-02-20)
Retinitis pigmentosa (RP) is a kind of inherited retinal degenerative diseases characterized by the progressive loss of photoreceptors. RP has been a conundrum without satisfactory countermeasures in clinic until now. Acetaldehyde dehydrogenase 2 (ALDH2), a major enzyme involved in aldehyde
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