SML1200
RO8191
≥98% (HPLC)
别名:
8-(1,3,4-Oxadiazol-2-yl)-2,4-bis(trifluoromethyl)-imidazo[1,2-a][1,8]naphthyridine, RO4948191
InChI key
GRHYZVJEXKTJOS-UHFFFAOYSA-N
SMILES string
FC(F)(F)c1nc2[n]3c(nc(c3)c4nnc[o]4)ccc2c(c1)C(F)(F)F
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 0.5 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
RO8191 is a potent and specific type I interferon receptor agonist that directly binds to IFN-α receptor 2 (IFNAR2).
RO8191 is an imidazonaphthyridine compound, which activates interferon (IFN) signals, IFN-stimulated genes (ISGs) expression and Janus kinase (JAK)/signal transducers and activators of transcription (STAT) phosphorylation.
RO8191 is an orally available, potent and specific type I interferon receptor agonist that directly binds to IFN-α receptor 2 (IFNAR2). RO8191 suppresses HCV replication without inducing host cell toxicity.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Hideyuki Konishi et al.
Scientific reports, 2, 259-259 (2012-02-23)
Most acute hepatitis C virus (HCV) infections become chronic and some progress to liver cirrhosis or hepatocellular carcinoma. Standard therapy involves an interferon (IFN)-α-based regimen, and efficacy of therapy has been significantly improved by the development of protease inhibitors. However
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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