SML1210
苹果酸阿莫曲坦
≥98% (HPLC)
别名:
3-[2-(Dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl )-1H-indole malate, PNU 180638
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 10 mg/mL, clear
storage temp.
−20°C
SMILES string
[S](=O)(=O)(N3CCCC3)Cc1cc2c([nH]cc2CCN(C)C)cc1.OC(CC(=O)O)C(=O)O
InChI
1S/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9)
InChI key
QHATUKWEVNMHRY-UHFFFAOYSA-N
Application
Almotriptan at an oral dose of 12.5 mg, is recommended to be safe for treating migraine.
Almotriptan is a serotonin 5HT-1B/1D-receptor agonist; antimigraine.
Biochem/physiol Actions
Almotriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine. Almotriptan has low nanomolar affinity for the 5-HT(1B) and 5-HT(1D) receptors while affinity for 5-HT receptors other than 5-HT(1B/1D) is substantially lower. Affinity for 5-HT(7) and 5-HT(1A) receptors was approximately 40 and 60 times lower than that for 5-HT(1B/1D) receptors, respectively.
Almotriptan is a serotonin 5HT-1B/1D-receptor agonist; antimigraine.
Still not finding the right product?
Explore all of our products under 苹果酸阿莫曲坦
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Kremena Saracheva et al.
Acta pharmaceutica (Zagreb, Croatia), 70(2), 239-247 (2020-01-20)
The introduction of the second generation triptans in clinical and experimental practice was a major progress in the pharmacotherapy of migraine. Frovatriptan is a second generation triptan with strong 5-HT1B/1D serotonergic agonism and low 5-HT1A/7 receptor affinity, while almotriptan possesses
Dose finding, placebo-controlled study of oral almotriptan in the acute treatment of migraine
Dahlof C, et al.
Neurology, 57(10), 1811-1817 (2001)
Long?term Efficacy and Safety of Oral Almotriptan: Interim Analysis of a 1?Year Open Study
Cabarrocas X, et al.
Headache, 41(1), 57-62 (2001)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1210-10MG | 04061832077239 |
| SML1210-50MG | 04061832077246 |