SML1236
(-)-尼古丁 酒石酸氢盐
≥98% (HPLC), acetylcholine receptor agonist, powder
别名:
(-)-1-甲基-2-(3-吡啶基)吡咯烷 (+)-酒石酸氢盐
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产品名称
(-)-尼古丁 酒石酸氢盐, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +20 to +26°, c = 1.0 in water
storage condition
desiccated
color
white to beige
solubility
H2O: 20 mg/mL, clear
storage temp.
room temp
SMILES string
CN1CCC[C@H]1C2=CC=CN=C2.C
InChI
1S/C10H14N2.CH4/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;/h2,4,6,8,10H,3,5,7H2,1H3;1H4/t10-;/m0./s1
InChI key
RYYKFQGHMYGLEL-PPHPATTJSA-N
Application
(−)-Nicotine hydrogen tartrate salt has been used in intracellular calcium imaging.
(−)-Nicotine hydrogen tartrate salt has been used as an agonist for acetylcholine receptor (AChr).
Biochem/physiol Actions
NHT is considered to be more stable than nicotine. Nicotine is highly addictive drug and is indirectly but strongly associated with tobacco related diseases. It helps to discontinue smoking. Nicotine might serve as a therapeutic agent in treating Alzheimer’s disease, Parkinson’s disease and ulcerative colitis.
原型烟酸乙酰胆碱受体激动剂;天然异构体。
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signalword
Danger
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 2
flash_point_f
289.8 °F
flash_point_c
143.2 °C
法规信息
涉药品监管产品
此项目有
Nicotine hydrogen tartrate loaded chitosan nanoparticles: Formulation, characterization and in vitro delivery from dry powder inhaler formulation.
Wang H, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 113, 118-131 (2017)
Mahmoud M Farag et al.
European journal of pharmacology, 720(1-3), 1-6 (2013-11-12)
The aim of this study was to evaluate the effects of chronic nicotine administration on bone mineral homeostasis in rapidly growing young rats in comparison to effects in adult male rats. Two doses of nicotine (3 and 4.5mg/kg/day, as nicotine
All muscarinic acetylcholine receptors (M 1-M 5) are expressed in murine brain microvascular endothelium.
Radu B M, et al.
Scientific Reports, 7(1), 5083-5083 (2017)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1236-1G | 04061825983561 |
| SML1236-50MG | 04061837107757 |