SML1624

JNJ-63533054

Name: JNJ-63533054
Brand: SIGMA

≥98% (HPLC)

别名:

(S)-3-Chloro-N-(2-oxo-2-((1-phenylethyl)amino)ethyl)benzamide

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₇ClN₂O₂

化学文摘社编号:

1802326-66-4

分子量:

316.78

UNSPSC Code:

12352200

NACRES:

NA.77

主要文件

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InChI key

MWDVCHRYCKXEBY-LBPRGKRZSA-N

SMILES string

Clc1cc(ccc1)C(=O)NCC(=O)N[C@@H](C)c2ccccc2

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -89 to -99°, c = 1 in ethanol

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

JNJ-63533054 is a potent and selective agonist of the orphan receptor hGPR139, a GPCR receptor expressed in the brain in circumventricular regions of the habenula and septum. JNJ-63533054 has an EC50 value of 16 nM, crosses the blood-brain barrier, and is orally available.

Potent and selective agonist of hGPR139 with an EC50 value of 16 nM