SML2160
R-568 盐酸盐
≥95% (HPLC)
别名:
2-氯-N-[（（1R）-1-（3-甲氧基苯基）乙基]-苯丙胺盐酸盐（1：1）, KRN 568盐酸盐, NPS-R 568盐酸盐, R 568盐酸盐, Tecalcet盐酸, 盐酸降钙素
登录查看公司和协议定价
选择尺寸
关于此项目
经验公式（希尔记法）:
C18H22ClNO · HCl
化学文摘社编号:
分子量:
340.29
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
方案
≥95% (HPLC)
表单
powder
旋光性
[α]/D +35 to +40°, c = 0.5 in chloroform-d
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
C[C@@H](NCCCC1=C(C=CC=C1)Cl)C2=CC=CC(OC)=C2.Cl
InChI
1S/C18H22ClNO.ClH/c1-14(16-8-5-10-17(13-16)21-2)20-12-6-9-15-7-3-4-11-18(15)19;/h3-5,7-8,10-11,13-14,20H,6,9,12H2,1-2H3;1H/t14-;/m1./s1
InChI key
YJXUXANREVNZLH-PFEQFJNWSA-N
相关类别
生化/生理作用
R-568 是钙敏感受体（CaSR）的正向别构调节剂，可增加对细胞外 Ca2+ 激活的敏感性。在大鼠中，口服 R-568 会降低 PTH 和 Ca2+ 的血浆水平，而在较高剂量时会降低降钙素的血浆水平。
钙敏感受体（CaSR）变构激动剂；拟钙剂
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Jenny Ying Lin Lu et al.
The Journal of pharmacology and experimental therapeutics, 331(3), 775-786 (2009-09-18)
Over 257 mutations in the human calcium-sensing receptor (hCaSR) gene have been reported. Heterozygous inactivating mutations can result in familial hypocalciuric hypercalcemia (FHH), whereas homozygous inactivating mutations can cause life-threatening neonatal severe hyperparathyroidism (NSHPT). Activating mutations in the hCaSR can
Fanny Bery et al.
Cancers, 12(4) (2020-04-08)
The mechanisms underlying neuroendocrine (NE) differentiation in prostate cancer (PCa) remain mostly uncharacterized. Since a deregulated calcium homeostasis has been reported in neuroendocrine prostate cancer (NEPC), we explored herein the link between NE differentiation and the calcium-sensing receptor (CaSR). CaSR
Asuka Masumoto et al.
Journal of atherosclerosis and thrombosis, 24(7), 716-724 (2016-11-15)
Vascular calcification (VC) is a risk factor of cardiovascular and all-cause mortality in patients with chronic kidney disease (CKD). CKD-mineral and bone metabolism disorder is an important problem in patients with renal failure. Abnormal levels of serum phosphate and calcium
Abhishek Aggarwal et al.
Biochimica et biophysica acta, 1853(9), 2158-2167 (2015-02-24)
The inverse correlation between dietary calcium intake and the risk of colorectal cancer (CRC) is well known, but poorly understood. Expression of the calcium-sensing receptor (CaSR), a calcium-binding G protein-coupled receptor is downregulated in CRC leading us to hypothesize that
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持