SML2160
R-568 盐酸盐
≥95% (HPLC)
别名:
2-氯-N-[（（1R）-1-（3-甲氧基苯基）乙基]-苯丙胺盐酸盐（1：1）, KRN 568盐酸盐, NPS-R 568盐酸盐, R 568盐酸盐, Tecalcet盐酸, 盐酸降钙素
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关于此项目
经验公式（希尔记法）:
C18H22ClNO · HCl
化学文摘社编号:
分子量:
340.29
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
desiccated
产品名称
R-568 盐酸盐, ≥95% (HPLC)
InChI
1S/C18H22ClNO.ClH/c1-14(16-8-5-10-17(13-16)21-2)20-12-6-9-15-7-3-4-11-18(15)19;/h3-5,7-8,10-11,13-14,20H,6,9,12H2,1-2H3;1H/t14-;/m1./s1
SMILES string
C[C@@H](NCCCC1=C(C=CC=C1)Cl)C2=CC=CC(OC)=C2.Cl
InChI key
YJXUXANREVNZLH-PFEQFJNWSA-N
assay
≥95% (HPLC)
form
powder
optical activity
[α]/D +35 to +40°, c = 0.5 in chloroform-d
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
相关类别
Biochem/physiol Actions
R-568 是钙敏感受体（CaSR）的正向别构调节剂，可增加对细胞外 Ca2+ 激活的敏感性。在大鼠中，口服 R-568 会降低 PTH 和 Ca2+ 的血浆水平，而在较高剂量时会降低降钙素的血浆水平。
钙敏感受体（CaSR）变构激动剂；拟钙剂
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Fanny Bery et al.
Cancers, 12(4) (2020-04-08)
The mechanisms underlying neuroendocrine (NE) differentiation in prostate cancer (PCa) remain mostly uncharacterized. Since a deregulated calcium homeostasis has been reported in neuroendocrine prostate cancer (NEPC), we explored herein the link between NE differentiation and the calcium-sensing receptor (CaSR). CaSR
Jenny Ying Lin Lu et al.
The Journal of pharmacology and experimental therapeutics, 331(3), 775-786 (2009-09-18)
Over 257 mutations in the human calcium-sensing receptor (hCaSR) gene have been reported. Heterozygous inactivating mutations can result in familial hypocalciuric hypercalcemia (FHH), whereas homozygous inactivating mutations can cause life-threatening neonatal severe hyperparathyroidism (NSHPT). Activating mutations in the hCaSR can
Asuka Masumoto et al.
Journal of atherosclerosis and thrombosis, 24(7), 716-724 (2016-11-15)
Vascular calcification (VC) is a risk factor of cardiovascular and all-cause mortality in patients with chronic kidney disease (CKD). CKD-mineral and bone metabolism disorder is an important problem in patients with renal failure. Abnormal levels of serum phosphate and calcium
Abhishek Aggarwal et al.
Biochimica et biophysica acta, 1853(9), 2158-2167 (2015-02-24)
The inverse correlation between dietary calcium intake and the risk of colorectal cancer (CRC) is well known, but poorly understood. Expression of the calcium-sensing receptor (CaSR), a calcium-binding G protein-coupled receptor is downregulated in CRC leading us to hypothesize that
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