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Merck
CN

SML2313

Higenamine hydrochloride

≥95% (HPLC)

别名:

Higenamine hydrochloride, (RS)-Norcoclaurine hydrochloride, (±)-1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6,7-Isoquinolinediol hydrochloride, (±)-Demethylcoclaurine, (±)-Norcoclaurine hydrochloride, (±)-O-Demethylcoclaurine hydrochloride, 1,2,3,4-Tetrahydro-1-[(4-hydroxyphenyl)methyl]-6,7-isoquinolinediol hydrochloride, dl-Demethylcoclaurine hydrochloride, (±)-Demethylcoclaurine hydrochloride

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关于此项目

经验公式（希尔记法）:
C16H17NO3 · HCl
化学文摘社编号:
11041-94-4
分子量:
307.77
UNSPSC Code:
12352116
NACRES:
NA.77
MDL number:
MFCD01717353

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产品名称

Higenamine hydrochloride, ≥95% (HPLC)

InChI

1S/C16H17NO3.ClH/c18-12-3-1-10(2-4-12)7-14-13-9-16(20)15(19)8-11(13)5-6-17-14;/h1-4,8-9,14,17-20H,5-7H2;1H

SMILES string

OC1=C(O)C=C(C(CC2=CC=C(O)C=C2)NCC3)C3=C1.Cl

InChI key

SWWQQSDRUYSMAR-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

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相关类别

Biochem/physiol Actions

Higenamine is an anti-inflammatory agent that protects cells from oxidant injury. Higenamine is a pharmacological modulator of heme oxygenase 1(HO-1). It also displays agonist activity at adrenergic β2 receptor.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000247303
0000247303
0000377403
0000315340
0000377403

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Wenjiang Duan et al.
Experimental and therapeutic medicine, 12(5), 3107-3112 (2016-11-25)
Existing in Ranunculaceae Aconitum and tomato, with the chemical name 1-phydroxybenzyl-1,2,3,4-tetrahy-droisoquinoline, higenamine is widely distributed in China. Higenamine's anti-inflammatory, antioxidant and anti-apoptotic effects have been identified in previous studies. The present study attempted to determine the protective effect of higenamine
Eisuke Kato et al.
Bioorganic & medicinal chemistry, 25(24), 6412-6416 (2017-10-27)
β2-Adrenergic receptor (β2AR) agonists are employed as bronchodilators to treat pulmonary disorders, but are attracting attention for their modulation of glucose handling and energy expenditure. Higenamine is a tetrahydroisoquinoline present in several plant species and has β2AR agonist activity, but
Xiaoxia An et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 95, 1710-1717 (2017-09-30)
Diabetic gastroparesis (DGP) is a common complication of diabetes mellitus (DM). The numerous clinical symptoms of DGP and the great cost on the treatment of DGP seriously lowered the patients' life quality. However, the pathogenic mechanism of DGP is still

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