SML2461
LM22B-10
≥98% (HPLC)
别名:
2,2′,2′′,2′′′-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakis[ethanol], 2,2′,2′,2′′′-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol
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关于此项目
经验公式（希尔记法）:
C27H33ClN2O4
化学文摘社编号:
分子量:
485.01
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
LM22B-10, ≥98% (HPLC)
InChI key
QCXQLSGBOUUVNH-UHFFFAOYSA-N
SMILES string
ClC1=CC=C(C(C2=CC=C(N(CCO)CCO)C=C2)C3=CC=C(N(CCO)CCO)C=C3)C=C1
assay
≥98% (HPLC)
form
powder
color
faint blue to green
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Biochem/physiol Actions
LM22B-10 is a brain penetrant, potent and selective TrkB and TrkC neurotrophin receptors agonist that improves cell survival and potently accelerated neurite outgrowth. LM22B-10 inhibits binding of BDNF to TrkB-expressing cells and NT-3 to TrkC-expressing cells.
brain penetrant, potent and selective TrkB and TrkC agonist
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Tao Zhang et al.
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Tao Yang et al.
Neuropharmacology, 110(Pt A), 343-361 (2016-06-24)
Neurotrophin (NT) receptors are coupled to numerous signaling networks that play critical roles in neuronal survival and plasticity. Several non-peptide small molecule ligands have recently been reported that bind to and activate specific tropomyosin-receptor kinase (Trk) NT receptors, stimulate their
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