SML2566
CL097
≥98% (HPLC)
别名:
2-(Ethoxymethyl)-3H-imidazo[4,5-c]quinolin-4-amine, CL 097, CL-097
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关于此项目
经验公式（希尔记法）:
C13H14N4O
化学文摘社编号:
分子量:
242.28
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[nH]1c2c(nc1COCC)c(nc3c2cccc3)N
InChI
1S/C13H14N4O/c1-2-18-7-10-16-11-8-5-3-4-6-9(8)15-13(14)12(11)17-10/h3-6H,2,7H2,1H3,(H2,14,15)(H,16,17)
InChI key
DEVCLHVFELRPIU-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to very dark brown
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
CL097 is an imidazoquinoline (IMDQ) derivative (IQD) with dual toll-like receptor 7 & 8 (TLR7 & TLR8; TLR7/8) agonist activity. CL097 is commonly employed in the concentration range from 0.5 μg/mL to 45 μg/mL for stimulating cell surface TLR7/8 in cultures and is reported to be a stronger TLR7 ligand than CL075.
Imidazoquinoline (IMDQ) derivative (IQD) with dual toll-like receptor 7 & 8 (TLR7 & TLR8; TLR7/8) agonist activity. A stronger TLR7 ligand than CL075.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Jueqi Chen et al.
Nature, 564(7734), 71-76 (2018-11-30)
The NLRP3 inflammasome, which has been linked to human inflammatory diseases, is activated by diverse stimuli. How these stimuli activate NLRP3 is unknown. Here we show that different NLRP3 stimuli lead to disassembly of the trans-Golgi network (TGN). NLRP3 is
Zhikuan Zhang et al.
Cell reports, 25(12), 3371-3381 (2018-12-20)
Toll-like receptor 7 (TLR7) is an innate immune receptor for single-stranded RNA (ssRNA) and has important roles in infectious diseases. We previously reported that TLR7 shows synergistic activation in response to two ligands, guanosine and ssRNA. However, the specific ssRNA
A León-Flores et al.
Immunology letters, 203, 70-79 (2018-09-22)
Recent evidence has revealed that PD-L1 is expressed in two functional forms, namely, a membrane-bound form (mPD-L1) and a soluble form (sPD-L1). The identification of the soluble form of PD-L1 represents the discovery of a new potential mechanism for the
Xinqiang Hong et al.
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 30(2), 197-208 (2018-06-05)
The aim of the present study was to investigate the effects of 5-fluorouracil (5-Fu) and oxaliplatin on the function and activation pathways of mouse dendritic cells (DCs), and to clarify whether 5-Fu/oxaliplatin combined with the CD1d-MC38/α-galactosylceramide (α-GC) tumor vaccine exhibits
Masaaki Okamoto et al.
The Journal of biological chemistry, 293(48), 18585-18600 (2018-10-05)
The innate immune system is important for the efficacy of vaccines, but excessive innate immune responses can cause adverse reactions after vaccination. Extracellular vesicles (EVs) are enriched in the blood and can deliver functional RNAs, such as microRNAs (miRNAs), to
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