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SML3700

TPC2-A1-P

Name: TPC2-A1-P
Brand: SIGMA

≥98% (HPLC), Two pore segment channel 2 (TCP2) agonist, powder

别名:

5-(5-Bromo-2-(trifluoromethoxy)phenyl)-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylic acid, TPC2 agonist H07

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关于此项目

经验公式（希尔记法）:

C₂₀H₂₁BrF₃NO₃

化学文摘社编号:

2804595-86-4

分子量:

460.28

UNSPSC Code:

12352200

NACRES:

NA.21

MDL number:

MFCD32878271

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

TPC2-A1-P, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

说明

Biochem/physiol Actions

Selective two pore segment channel 2 (TCP2) agonist that preferentially mimics the Na+ signals-inducing action of PI(3,5)P2.

TPC2-A1-P is a selective two pore segment channel 2 (TCP2) agonist that mimics the action of PI(3,5)P2 where it preferentially induces Na+ signals (EC50 = 0.6 µM). In contrast, TPC2-A1-N is a much weaker Ca2+ current inducer when compared to NAADP and TPC2-A1-N. TPC2-A1-P, but not the Ca2+ signals agonist TPC2-A1-N, activates TPC2-dependent lysosomal exocytosis (30 µM, murine macrophages), while TPC2-A1-N, but not TPC2-A1-P, causes TPC2-dependent alkalinization of lysosomal lumen Ca2+ stores (10 µM, TPC2-expressing HeLa cells).

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth

Cell Chemical Biology, 28(8) (2021)

Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors.

Philipp Rühl et al.

Scientific reports, 11(1), 8313-8313 (2021-04-17)

The cation channel TRPML1 is an important regulator of lysosomal function and autophagy. Loss of TRPML1 is associated with neurodegeneration and lysosomal storage disease, while temporary inhibition of this ion channel has been proposed to be beneficial in cancer therapy.

The ethoxycarbonyl group as both activating and protective group in N-acyl-Pictet-Spengler reactions using methoxystyrenes. A short approach to racemic 1-benzyltetrahydroisoquinoline alkaloids.

Marco Keller et al.

Beilstein journal of organic chemistry, 17, 2716-2725 (2021-11-23)

We present a systematic investigation on an improved variant of the N-acyl-Pictet-Spengler condensation for the synthesis of 1-benzyltetrahydroisoquinolines, based on our recently published synthesis of N-methylcoclaurine, exemplified by the total syntheses of 10 alkaloids in racemic form. Major advantages are

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