Levonorgestrel

Name: Levonorgestrel
Brand: SIGMA

≥98% (HPLC)

别名:

(17α)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one, 13-Ethyl-17-ethynyl-17β-hydroxy-4-gonen-3-one, 13-Ethyl-17-hydroxy-18,19-dinor-17α-pregn-4-en-20-yn-3-one, D(−)-Norgestrel, D-Norgestrel, LNG

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About This Item

经验公式（希尔记法）:

C₂₁H₂₈O₂

CAS Number:

797-63-7

分子量:

312.45

MDL编号:

MFCD01546387

UNSPSC代码:

12352200

NACRES:

NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

旋光性

[α]/D -28 to -36° (C= 1.0g/100 ml in CDCl3)

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

-10 to -25°C

SMILES字符串

O[C@@]1([C@@]2([C@H]([C@H]3[C@@H]([C@H]4CCC(=O)C=C4CC3)CC2)CC1)CC)C#C

InChI key

WWYNJERNGUHSAO-XUDSTZEESA-N

生化/生理作用

Orally bioavailable synthetic progestational agent that reversibly binds to progesterone receptors with high-affinity in the hypothalamus, pituitary gland, and uterus.

Levonorgestrel (D-Norgestrel) is an orally bioavailable synthetic progestational agent that reversibly binds to progesterone receptors with high-affinity in the hypothalamus, pituitary gland, and uterus. Levonorgestrel inhibits the release of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). D(−)-Norgestrel prevents fertilization by altering cervical mucus consistency, and interfering with the endometrial lining, making it less receptive to implantation. Levonorgestrel (LNG) can be used alone or in combination with estrogen during hormone replacement therapy.