SML4026
ZH8651 hydrochloride
≥98% (HPLC)
别名:
2-(4-Bromophenyl)ethan-1-amine hydrochloride, 4-Bromobenzene-ethanamine hydrochloride, 4-Bromophenethylamine hydrochloride, p-Bromophenethylamine hydrochloride
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
BrC1=CC=C(C=C1)CCN.Cl
InChI
1S/C8H10BrN.ClH/c9-8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChI key
ZHAWIPAHUYMLDV-UHFFFAOYSA-N
相关类别
生化/生理作用
Orally available, potent, and selective agonist of Trace amine-associated receptor 1 (TAAR1); dual activator of Gs and Gq in mTAAR1/hTAAR1.
ZH8651 is an orally available, potent, and selective agonist of Trace amine-associated receptor 1 (TAAR1). ZH8651 is dual activator of Gs and Gq in mTAAR1/hTAAR1 (EC50 = 9,85 nM (Gs), 66.5 nM Gq). ZH8651 alleviates MK-801-induced schizophrenia-like phenotypes without inducing catalepsy in mice.
ZH8651 is an orally available, potent, and selective agonist of Trace amine-associated receptor 1 (TAAR1). ZH8651 is dual activator of Gs and Gq in mTAAR1/hTAAR1 (EC50 = 9,85 nM (Gs), 66.5 nM Gq). ZH8651 alleviates MK-801-induced schizophrenia-like phenotypes without inducing catalepsy in mice.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Pan Shang et al.
Cell, 186(24), 5347-5362 (2023-11-15)
Trace amine-associated receptor 1 (TAAR1) senses a spectrum of endogenous amine-containing metabolites (EAMs) to mediate diverse psychological functions and is useful for schizophrenia treatment without the side effects of catalepsy. Here, we systematically profiled the signaling properties of TAAR1 activation
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