SML4027
ZH8659 hydrochloride
≥98% (HPLC)
别名:
2-[4-(Furan-2-yl)phenyl]ethan-1-amine hydrochloride, 4-(2-Furanyl)benzene-ethanamine hydrochloride
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关于此项目
经验公式（希尔记法）:
C12H13NO ·HCl
分子量:
223.70
NACRES:
NA.21
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
NCCC1=CC=C(C2=CC=CO2)C=C1.Cl
InChI
1S/C12H13NO.ClH/c13-8-7-10-3-5-11(6-4-10)12-2-1-9-14-12;/h1-6,9H,7-8,13H2;1H
InChI key
PIDHDDFXZYDGMH-UHFFFAOYSA-N
Biochem/physiol Actions
Orally available, potent and selective agonist of Trace amine-associated receptor 1 (TAAR1); potent Gq-selective agonist of mTAAR1/hTAAR1.
ZH8659 is an orally available, potent and selective agonist of Trace amine-associated receptor 1 (TAAR1). ZH8659 is a potent Gq-selective agonist of mTAAR1/hTAAR1 (EC50 = 2.6 nM (Gq)). ZH8659 alleviates MK-801-induced schizophrenia-like phenotypes without inducing catalepsy in mice.
ZH8659 is an orally available, potent and selective agonist of Trace amine-associated receptor 1 (TAAR1). ZH8659 is a potent Gq-selective agonist of mTAAR1/hTAAR1 (EC50 = 2.6 nM (Gq)). ZH8659 alleviates MK-801-induced schizophrenia-like phenotypes without inducing catalepsy in mice.
Disclaimer
Hygroscopic
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Pan Shang et al.
Cell, 186(24), 5347-5362 (2023-11-15)
Trace amine-associated receptor 1 (TAAR1) senses a spectrum of endogenous amine-containing metabolites (EAMs) to mediate diverse psychological functions and is useful for schizophrenia treatment without the side effects of catalepsy. Here, we systematically profiled the signaling properties of TAAR1 activation
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML4027-25MG | 04065272123624 |
| SML4027-5MG | 04065272123631 |