质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
NCCC1=CC=C(C2=CC=CO2)C=C1.Cl
InChI
1S/C12H13NO.ClH/c13-8-7-10-3-5-11(6-4-10)12-2-1-9-14-12;/h1-6,9H,7-8,13H2;1H
InChI key
PIDHDDFXZYDGMH-UHFFFAOYSA-N
相关类别
生化/生理作用
Orally available, potent and selective agonist of Trace amine-associated receptor 1 (TAAR1); potent Gq-selective agonist of mTAAR1/hTAAR1.
ZH8659 is an orally available, potent and selective agonist of Trace amine-associated receptor 1 (TAAR1). ZH8659 is a potent Gq-selective agonist of mTAAR1/hTAAR1 (EC50 = 2.6 nM (Gq)). ZH8659 alleviates MK-801-induced schizophrenia-like phenotypes without inducing catalepsy in mice.
ZH8659 is an orally available, potent and selective agonist of Trace amine-associated receptor 1 (TAAR1). ZH8659 is a potent Gq-selective agonist of mTAAR1/hTAAR1 (EC50 = 2.6 nM (Gq)). ZH8659 alleviates MK-801-induced schizophrenia-like phenotypes without inducing catalepsy in mice.
免责声明
Hygroscopic
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Pan Shang et al.
Cell, 186(24), 5347-5362 (2023-11-15)
Trace amine-associated receptor 1 (TAAR1) senses a spectrum of endogenous amine-containing metabolites (EAMs) to mediate diverse psychological functions and is useful for schizophrenia treatment without the side effects of catalepsy. Here, we systematically profiled the signaling properties of TAAR1 activation
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