质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
OC(C1=CC=C(NCC2=CC=C(C3(C(C)(C)C)OCC(C)(C)CO3)C=C2)C(OC)=C1)=O
InChI key
CZSPKEVHLRWAFC-UHFFFAOYSA-N
相关类别
生化/生理作用
Potent STING allosteric agonist that induces a STING-mediated immune responses in cells.
NVS-STG2 is a potent STING (stimulator of interferon genes) allosteric agonist (AC=5.2 µM) that induces a STING-mediated immune responses in cells. It elicits potent antitumor activity in animal models. NVS-STG2 acts as molecular glue that binds the transmembrane domains of the neighboring STING dimers.
NVS-STG2 is a potent STING (stimulator of interferon genes) allosteric agonist (AC=5.2 µM) that induces a STING-mediated immune responses in cells. It elicits potent antitumor activity in animal models. NVS-STG2 acts as molecular glue that binds the transmembrane domains of the neighboring STING dimers.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Jie Li et al.
Nature chemical biology, 20(3), 365-372 (2023-10-13)
Stimulator of interferon genes (STING) is a dimeric transmembrane adapter protein that plays a key role in the human innate immune response to infection and has been therapeutically exploited for its antitumor activity. The activation of STING requires its high-order
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