SRE0001
胃蛋白酶 来源于猪胃粘膜
Suitable for manufacturing of diagnostic kits and reagents, lyophilized powder, ≥3200 units/mg protein
别名:
胃液素 来源于猪胃, 胃蛋白酶 A
质量水平
表单
lyophilized powder
比活
≥3200 units/mg protein
分子量
35 kDa
杂质
salt, essentially free
颜色
white to off-white
UniProt登记号
应用
diagnostic assay manufacturing
运输
wet ice
储存温度
−20°C
基因信息
pig ... LOC396892(396892)
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应用
胃蛋白酶切割可用于产生抗体的F(ab′)2 片段。有关胃蛋白酶的更多信息，请访问 www.sigma-aldrich.com/enzymeexplorer。
生化/生理作用
优先裂解：P1 和 P1′ 位的疏水性和芳族残基。降解胰岛素 β 链中的 Phe-Val、Gln-His、Glu-Ala、Ala-Leu、Leu-Tyr、Tyr-Leu、Gly-Phe、Phe-Phe 和 Phe-Tyr 键
分析说明
E1%/280法测定蛋白
最适pH值为2-4。在4 M尿素和3 M盐酸胍中可保持活性。在60°C时稳定。胃蛋白酶在pH 8.0-8.5下发生不可逆灭活。
其他说明
一个单位将在 37°C、pH2.0 下每分钟产生 ΔA 280 0.001，以 TCA 可溶产物计，以血红蛋白为底物。（最终体积 = 16 mL。）
查看有关 胃蛋白酶 的更多信息，请访问 www.sigma-aldrich.com/enzymeexplorer。
警示用语：
Danger
危险分类
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
低风险生物材料
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
J A Green et al.
Reviews of reproduction, 3(1), 62-69 (1998-03-24)
The pregnancy-associated glycoproteins (PAGs) were first described as placental antigens of cattle that were also present in the blood serum of the mother after implantation. Molecular cloning studies have shown that they are members of the aspartic proteinase gene family
Joseph S Fruton
The Quarterly review of biology, 77(2), 127-147 (2002-07-02)
Studies on gastric digestion during 1820-1840 led to the discovery of pepsin as the agent which, in the presence of stomach acid, causes the dissolution of nutrients such as meat or coagulated egg white. Soon afterward it was shown that
Christie McCracken et al.
Chemical research in toxicology, 26(10), 1514-1525 (2013-09-14)
Toxicity of commercial nanoparticles of titania, silica, and zinc oxides is being investigated in this in vitro study. Particles of these compositions are found in many food items, and thus this study is directed toward particle behavior in simulated digestion
F Halter et al.
The Yale journal of biology and medicine, 69(1), 99-104 (1997-01-01)
Chronic Helicobacter pylori infection causes a slight postprandial hypergastinemia, generally referred to as exaggerated or inappropriate gastrin release. This can be ablated by eradication of this infective agent. The expectations that this would further unravel the mysteries of the pathogenesis
Autonomic control of secretion of gastric acid and pepsin.
K Bech
Journal of autonomic pharmacology, 9(6), 419-428 (1989-12-01)
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