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安全信息

SRP6274

Sigma-Aldrich

Furin human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

别名:

FUR, FURIN, PACE, PCSK3, SPC1

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选择尺寸

10 MG
CN¥532.96
50 MG
CN¥1,783.43
100 MG
CN¥2,154.06

CN¥532.96


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选择尺寸

变更视图
10 MG
CN¥532.96
50 MG
CN¥1,783.43
100 MG
CN¥2,154.06

About This Item

UNSPSC代码:
12352204
NACRES:
NA.32

CN¥532.96


有货详情


生物来源

human

重组

expressed in HEK 293 cells

标签

6-His tagged (C-terminus)

方案

≥95% (SDS-PAGE)

表单

lyophilized powder

分子量

calculated mol wt 66.5 kDa
observed mol wt 55-66 kDa (DTT-reduced. Asp 108 is the predicted N-terminus .)

包装

pkg of 10 μg

杂质

<1 EU/μg endotoxin (LAL test)

UniProt登记号

运输

wet ice

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I8260I8265I9140
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

shipped in

dry ice

shipped in

wet ice

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

grade

technical grade

grade

reagent grade

grade

technical grade

grade

technical grade

assay

≥80% (SDS-PAGE)

assay

~95% (HPLC)

assay

≥80% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

一般描述

Furin also known as paired basic Amino acid Cleaving Enzyme (PACE), is an enzyme which belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. Furin is enriched in the Golgi apparatus, where it functions to cleave other proteins into their mature/active forms. The expression of furin in T-cells is required for maintenance of peripheral immune tolerance. Furin cleaves proteins just downstream of a basic amino acid target sequence (canonically, Arg-X-(Arg/Lys) -Arg′). PACE is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. In addition to processing cellular precursor proteins, furin is also utilized by a number of pathogens. For example, the envelope proteins of viruses such as HIV, influenza and dengue fever viruses must be cleaved by furin or furin-like proteases to become fully functional. PACE also play a role in tumor progression.

外形

Lyophilized from 0.22 μm filtered solution in MES, Brij-35. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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    Gerlândia Neres Pontes et al.
    FEMS immunology and medical microbiology, 47(3), 405-413 (2006-07-29)
    We evaluated the ability of human maternal and cord serum antibodies to protect mice challenged with live Escherichia coli serotype O6:K2ac (E. coli O6). Mice received paired maternal or cord serum pools before a challenge with E. coli O6 to
    Simone F A Wouters et al.
    Bioconjugate chemistry, 31(3), 656-662 (2020-01-08)
    Bioluminescent antibodies represent attractive detection agents in both bioanalytical assays and imaging. Currently, their preparation relies on genetic fusion of luciferases to antibodies or nonspecific chemical conjugation strategies. Here, we report a generic method to generate well-defined covalent antibody-luciferase conjugates
    Chuan Chiang-Ni et al.
    Frontiers in microbiology, 9, 2592-2592 (2018-11-15)
    Group A streptococci (GAS) with spontaneous mutations in the CovR/CovS regulatory system are more invasive and related to severe manifestations. GAS can replicate inside phagocytic cells; therefore, phagocytic cells could serve as the niche to select invasive covS mutants. Nonetheless
    K M Dziegielewska et al.
    The Histochemical journal, 33(8), 443-451 (2002-04-05)
    Fetuin, a foetal protein of unknown function, has been shown to be expressed in both the immune and nervous systems, especially during development. Here, we show for the first time, that fetuin is abundantly present in many cells of the
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    Biotechnology and bioengineering, 102(4), 1119-1130 (2008-10-30)
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