T0678
Anti-Tryptophan Hydroxylase Antibody
mouse monoclonal, WH-3
别名:
Anti-TPH
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关于此项目
Conjugate:
unconjugated
Clone:
WH-3, monoclonal
Application:
ARR, ELISA (i), IHC, WB
Citations:
74
产品名称
色氨酸羟化酶单克隆抗体 小鼠抗, clone WH-3, ascites fluid
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
WH-3, monoclonal
mol wt
antigen 55 kDa
contains
15 mM sodium azide
species reactivity
human, monkey, rabbit, rat
technique(s)
immunohistochemistry: suitable, indirect ELISA: suitable, microarray: suitable, western blot: 1:1,000 using rabbit pineal gland extract
isotype
IgG3
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TPH1(7166), TPH2(121278)
rat ... Tph1(24848), Tph2(317675)
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General description
单克隆抗色氨酸羟化酶（小鼠IgG3 亚型）来自于小鼠骨髓瘤细胞和BALB/c小鼠脾细胞融合产生的WH-3杂交瘤细胞。色氨酸羟化酶(TPH；L-色氨酸四氢蝶啶：氧气氧化还原酶；EC 1.14.16.4），用于合成血清素的限速酶，是一种只存在于含血清素的神经元中的特殊酶。
色氨酸羟化酶1基因（TPH1）是一个含444个氨基酸的蛋白质，由跨越29kbp的基因编码，位于具有11个外显子的人染色体11p15.3-p14上。该酶表达于肠、脾、胸腺、垂体以及松果体中。
Immunogen
重组兔色氨酸羟化酶。
Application
小鼠源抗色氨酸羟化酶单克隆抗体可用于：
- 酶联免疫吸附测定(ELISA)
- 免疫组织化学
- 免疫印迹
- 免疫细胞化学
Biochem/physiol Actions
色氨酸羟化酶1基因（TPH1）催化5-羟色氨酸的合成，而5-羟色氨酸是神经递质5-羟色胺的前体。基因表达的变化会影响反应抑制过程中前额叶皮层的激活。TPH1基因的突变会导致精神分裂症，女性肠易激综合征（IBS），自杀行为和抑郁症。编码的蛋白质在调节心血管功能中起着至关重要的作用。
该抗体可与色氨酸羟化酶发生特异性反应。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
动物来源生物产品
此项目有
Kadri Andre et al.
BMC psychiatry, 13, 118-118 (2013-04-20)
In major depression, one of the candidate genes possibly affecting the risk and severity of symptoms has been found to be tryptophan hydroxylase (TPH1). Variation in treatment response to antidepressive agents according to TPH1 genotype has also been found in
Honghai Zhang et al.
Epilepsia, 57(8), 1228-1235 (2016-06-16)
The DBA/1 mouse is a relevant animal model of sudden unexpected death in epilepsy (SUDEP), as it exhibits seizure-induced respiratory arrest (S-IRA) evoked by acoustic stimulation, followed by cardiac arrhythmia and death. Defects in serotonergic neurotransmission may contribute to S-IRA.
Brain tryptophan hydroxylase: purification of, production of antibodies to, and cellular and ultrastructural localization in serotonergic neurons of rat midbrain
Joh TH, et al.
Proceedings of the National Academy of Sciences of the USA, 72(9), 3575-3579 (1975)
Anthony C Ruocco et al.
Neuropsychology, 30(1), 18-27 (2015-12-29)
The tryptophan hydroxylase 1 gene (TPH1) catalyzes the formation of 5-hydroxytryptophan, a precursor to the neurotransmitter serotonin. Variations in the gene encoding this enzyme may underlie difficulties in impulse control; however, the proximate relationship between risk alleles for polymorphisms in
Chao-Chuan Wang et al.
The international journal of neuropsychopharmacology, 16(9), 2027-2039 (2013-07-05)
Accumulating evidence suggests that dysfunction of the amygdala is related to abnormal fear processing, anxiety, and social behaviors noted in autistic spectrum disorders (ASDs). In addition, studies have shown that disrupted brain serotonin homeostasis is linked to ASD. With a
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Instructions
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T0678-100UL | 04061837726309 |
| T0678-.2ML | 04061837335761 |
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