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文件

T144

(±)-沙利度胺

Name: (±)-沙利度胺
Brand: SIGMA

≥98%, powder

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别名:

(±)-2-（2,6-二氧代-3-哌啶基）-1H-异吲哚-1,3 (2H)-二酮

经验公式（希尔记法）:

C₁₃H₁₀N₂O₄

CAS号:

50-35-1

分子量:

258.23

EC 号:

200-031-1

MDL编号:

MFCD00153873

eCl@ss:

39180303

PubChem化学物质编号:

24278765

NACRES:

NA.77

检测方案

≥98%

形式

powder

reaction suitability

reagent type: ligand

颜色

white

溶解性

DMSO: 20 mg/mL, clear

创始人

Celgene

SMILES string

O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1

InChI

1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)

InChI key

UEJJHQNACJXSKW-UHFFFAOYSA-N

Gene Information

human ... CRBN(51185) , CUL4A(8451) , DDB1(1642) , LITAF(9516) , RBX1(9978) , TNF(7124)
mouse ... Nos2(18126)
rat ... Nos1(24598)

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应用

沙利度胺已被用于阿尔茨海默病 (AD) 小鼠模型的神经病理学研究。该研究报道，长期服用沙利度胺可引起 β-分泌酶抑制，继而减轻类淀粉样病理。此外，沙利度胺也被用于评价其致畸功能。沙利度胺可影响人胚胎干细胞和诱导多能干细胞分化过程中的内胚层分化和神经发育。

生化/生理作用

(±)-沙利度胺选择性抑制肿瘤坏死因子 α 的生物合成（TNF-α)。它还作为血管生成抑制剂、免疫抑制剂、镇静剂和致畸剂发挥作用。此外，已知沙利度胺在难治性多发性骨髓瘤中表现出抗肿瘤功能。

特点和优势

该化合物由 Celgene 开发。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表，点击这里。

制备说明

沙利度胺可溶于 DMSO，浓度超过 20 mg/mL。不溶于水和乙醇。

应用

产品编号

说明

价格

警示用语：

Danger

危险声明

H301 - H312 - H360D

预防措施声明

P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364

危险分类

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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示例

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货号

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application for HPLC

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