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Merck
CN

T144

Sigma-Aldrich

(±)-沙利度胺

≥98%, beta-secretase inhibitor, powder

别名:

(±)-2-（2,6-二氧代-3-哌啶基）-1H-异吲哚-1,3 (2H)-二酮

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关于此项目

经验公式（希尔记法）:
C13H10N2O4
化学文摘社编号:
50-35-1
分子量:
258.23
EC 号:
200-031-1
MDL编号:
MFCD00153873
UNSPSC代码:
12352111
eCl@ss:
39180303
PubChem化学物质编号:
24278765
NACRES:
NA.77

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产品名称

(±)-沙利度胺, ≥98%, powder

ligand

thalidomide

方案

≥98%

表单

powder

反应适用性

reagent type: ligand

颜色

white

溶解性

DMSO: 20 mg/mL, clear

创始人

Celgene

SMILES字符串

O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1

InChI

1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)

InChI key

UEJJHQNACJXSKW-UHFFFAOYSA-N

基因信息

human ... CRBN(51185), CUL4A(8451), DDB1(1642), LITAF(9516), RBX1(9978), TNF(7124)
mouse ... Nos2(18126)
rat ... Nos1(24598)

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相关类别

应用

沙利度胺已被用于阿尔茨海默病 (AD) 小鼠模型的神经病理学研究。该研究报道，长期服用沙利度胺可引起 β-分泌酶抑制，继而减轻类淀粉样病理。此外，沙利度胺也被用于评价其致畸功能。沙利度胺可影响人胚胎干细胞和诱导多能干细胞分化过程中的内胚层分化和神经发育。

生化/生理作用

(±)-沙利度胺选择性抑制肿瘤坏死因子 α 的生物合成（TNF-α)。它还作为血管生成抑制剂、免疫抑制剂、镇静剂和致畸剂发挥作用。此外，已知沙利度胺在难治性多发性骨髓瘤中表现出抗肿瘤功能 。

特点和优势

该化合物由 Celgene 开发。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表， 点击这里 。

制备说明

沙利度胺可溶于 DMSO，浓度超过 20 mg/mL。不溶于水和乙醇。

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险声明

H301,H312,H360D

危险分类

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000238502
0000234466
0000218013
0000234466
0000238502

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Marzia Lazzerini et al.
JAMA, 310(20), 2164-2173 (2013-11-28)
Pediatric-onset Crohn disease is more aggressive than adult-onset disease, has high rates of resistance to existing drugs, and can lead to permanent impairments. Few trials have evaluated new drugs for refractory Crohn disease in children. To determine whether thalidomide is
S Singhal et al.
The New England journal of medicine, 341(21), 1565-1571 (1999-11-24)
Patients with myeloma who relapse after high-dose chemotherapy have few therapeutic options. Since increased bone marrow vascularity imparts a poor prognosis in myeloma, we evaluated the efficacy of thalidomide, which has antiangiogenic properties, in patients with refractory disease. Eighty-four previously
Yoav Mayshar et al.
Journal of cellular and molecular medicine, 15(6), 1393-1401 (2010-06-22)
Teratogens are substances that may cause defects in normal embryonic development while not necessarily being toxic in adults. Identification of possible teratogenic compounds has been historically beset by the species-specific nature of the teratogen response. To examine teratogenic effects on
Tomomi Noguchi et al.
Bioorganic & medicinal chemistry letters, 15(24), 5509-5513 (2005-09-27)
5-Hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (5HPP-33: 10), which was obtained during our previous structural development studies on thalidomide, was revealed to possess potent anti-angiogenic activity in a human umbilical vein endothelial cell (HUVEC) assay. Thalidomide (1) and its metabolite, 5-hydroxythalidomide (5-HT: 2), which possesses
Yang Yang et al.
Pharmaceutics, 15(4) (2023-04-28)
Thalidomide (THD), a synthetic derivative of glutamic acid, was initially used as a sedative and antiemetic until the 1960s, when it was found to cause devastating teratogenic effects. However, subsequent studies have clearly demonstrated the anti-inflammatory, anti-angiogenic, and immunomodulatory properties
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