Merck
CN

T1827

Sigma-Aldrich

Monoclonal Anti-TBP 小鼠抗

clone 58C9, purified from hybridoma cell culture

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别名:
Anti-GTF2D, Anti-GTF2DI, Anti-SCA17, Anti-TATA box binding protein, Anti-TFIID
MDL编号:
NACRES:
NA.41

生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

purified from hybridoma cell culture

antibody product type

primary antibodies

克隆

58C9

分子量

antigen ~42 kDa

species reactivity

Sf9 cell line, human, yeast, Drosophila melanogaster

technique(s)

immunoprecipitation (IP): suitable
western blot: 1-2 μg/mL using nuclear extracts of D.Mel cells

同位素/亚型

IgG2b

UniProt登记号

运输

dry ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

Drosophila melanogaster ... Tbp(37476)
human ... TBP(6908)

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R4903SAB4200479M6818
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

clone

58C9

clone

4D11, monoclonal

clone

SET51, monoclonal

clone

Mec-168, monoclonal

mol wt

antigen ~42 kDa

mol wt

antigen ~68 kDa

mol wt

antigen ~37 kDa

mol wt

antigen ~75 kDa

species reactivity

Sf9 cell line, human, yeast, Drosophila melanogaster

species reactivity

bovine, newt, chicken, human, monkey, mouse

species reactivity

rat, human, mouse

species reactivity

rat, human, mouse

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一般描述

Monoclonal Anti-TBP (mouse IgG2b isotype) is derived from the hybridoma 58C9 produced by the fusion of mouse myeloma cells and splenocytes from Swiss Webster mice immunized with Drosophila TFIID complex. Transcription factor IID (TFIID) complex contains the TATA-binding protein (TBP) and over a dozen of TBP-associated factors (TAFs).
TBP (TATA-binding protein) is encoded by the gene mapped to human chromosome 6q27. The encoded protein is a key constituent of RNA polymerase II transcription apparatus in eukaryotic cells.

免疫原

Drosophila TFIID complex.

应用

Monoclonal Anti-TBP antibody produced in mouse has been used in:
  • immunoblotting
  • co-immunoprecipitation
  • immunohistochemistry

生化/生理作用

TBP facilitates promoter recognition with the help of the sequence-specific binding of the TATA element found in many promoters.
The TBP (TATA-binding protein) gene encodes a subunit of TFIIIB (transcription factor IIIB) complex and recognizes the TATA box in the DNA. Thus, it plays an important role in RNA polymerase II transcription machinery. TBP is known to induce stress granule formation in hepatitis B viral infection. Mutation in the gene is associated with the development of spinocerebellar ataxia 17 (SCA17).

目标描述

TBP encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of tr

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

12 - Non Combustible Liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

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    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Which light chain is used in Product T1827, Monoclonal Anti-TBP antibody, clone 58C9?

    The light chain for Product T1827, Monoclonal Anti-TBP antibody, clone 58C9 is a lambda light chain.

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Enhanced Human Decidual Cell-Expressed FKBP51 May Promote Labor-Related Functional Progesterone Withdrawal
Schatz F, et al.
The American Journal of Pathology, 185(9), 2402-2411 (2015)
K Nakamura et al.
Human molecular genetics, 10(14), 1441-1448 (2001-07-13)
Genetic etiologies of at least 20% of autosomal dominant cerebellar ataxias (ADCAs) have yet to be clarified. We identified a novel spinocerebellar ataxia (SCA) form in four Japanese pedigrees which is caused by an abnormal CAG expansion in the TATA-binding
Taspase1 processing alters TFIIA cofactor properties in the regulation of TFIID.
Malecova B
Transcription, 6, 21-32 (2015)
Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation.
Gouge J
Nature Communications, 8, 130-130 (2017)
TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family.
Rabenstein MD
Proceedings of the National Academy of Sciences of the USA, 96, 4791-4796 (1999)

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