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Merck
CN

T2528

Sigma-Aldrich

Terbutaline hemisulfate salt

β-adrenoceptor agonist

别名:

2-t-Butylamino-1-(3,5-dihydroxyphenyl)ethanol, 5-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol hemisulfate salt

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关于此项目

线性分子式:
C12H19NO3 · 1/2H2SO4
化学文摘社编号:
23031-32-5
分子量:
274.32
EC 号:
245-386-3
MDL编号:
MFCD00079584
UNSPSC代码:
12352200
PubChem化学物质编号:
24278729
NACRES:
NA.77

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产品名称

Terbutaline hemisulfate salt,

溶解性

H2O: soluble 100 mg/mL, clear to slightly hazy, colorless to yellow

创始人

Novartis

SMILES字符串

OS(O)(=O)=O.CC(C)(C)NCC(O)c1cc(O)cc(O)c1.CC(C)(C)NCC(O)c2cc(O)cc(O)c2

InChI

1S/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)

InChI key

KFVSLSTULZVNPG-UHFFFAOYSA-N

基因信息

human ... ADRB1(153), ADRB2(154), ADRB3(155)

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相关类别

应用

Terbutaline hemisulfate has been used as a reference standard for the determination of β agonist residues in meat4. It has also been used as a standard for developing LC-MS-MS based techniques for the analysis of veterinary drugs5.

生化/生理作用

Terbutaline is a β-adrenoceptor agonist and is known to function as a bronchodilator. Studies have reported that terbutaline is potent inhibitor of premature labor6.

特点和优势

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

制备说明

Terbutaline hemisulfate salt dissolves in water at 100 mg/ml to yield a colorless to yellow, clear to slightly hazy solution.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H361,H370

危险分类

Repr. 2 - STOT SE 1

靶器官

Cardio-vascular system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN4064
BCCJ7739
BCCC7481
BCBV3715
BCBQ7406V

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Anthony M J Sanchez et al.
European journal of applied physiology, 113(2), 411-418 (2012-07-07)
This study aimed to investigate the effects on a possible improvement in aerobic and anaerobic performance of oral terbutaline (TER) at a supra-therapeutic dose in 7 healthy competitive male athletes. On day 1, ventilatory threshold, maximum oxygen uptake [Formula: see
Zbys Fedorowicz et al.
The Cochrane database of systematic reviews, 5(5), CD008585-CD008585 (2012-05-18)
Dysmenorrhoea is a common gynaecological complaint that can affect as many as 50% of premenopausal women, 10% of whom suffer severely enough to be rendered incapacitated for one to three days during each menstrual cycle. Primary dysmenorrhoea is where women
Jodie M Dodd et al.
The Cochrane database of systematic reviews, 12, CD003927-CD003927 (2012-12-14)
Some women who have threatened to give birth prematurely, subsequently settle. They may then take oral tocolytic maintenance therapy to prevent preterm birth and to prolong gestation. To assess the effects of oral betamimetic maintenance therapy after threatened preterm labour
I Ingemarsson
American journal of obstetrics and gynecology, 125(4), 520-524 (1976-06-15)
The effect of terbutaline, a "selective" beta2-receptor stimulator, was compared with that of placebo in 30 patients in premature labor. Treatment consisted of an intravenous infusion for at least 8 hours, and then of subcutaneous injections four times daily for
Theodore A Slotkin et al.
Neurotoxicology and teratology, 36, 91-96 (2012-07-21)
Terbutaline, a β2-adrenoceptor agonist, is used off-label for long-term management of preterm labor; such use is associated with increased risk of neurodevelopmental disorders, including autism spectrum disorders. We explored the mechanisms underlying terbutaline's effects on development of peripheral sympathetic projections
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