T3516
硫代磺素T
Powder
别名:
硫磺素T, 碱性黄1
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关于此项目
经验公式（希尔记法）:
C17H19ClN2S
化学文摘社编号:
分子量:
318.86
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
EC Number:
219-228-9
MDL number:
Beilstein/REAXYS Number:
3922452
产品名称
硫代磺素T, used as stain for amyloid
InChI
1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1
InChI key
JADVWWSKYZXRGX-UHFFFAOYSA-M
SMILES string
[Cl-].CN(C)c1ccc(cc1)-c2sc3cc(C)ccc3[n+]2C
form
powder
composition
Dye content, ≥65%
solubility
methanol: 1 mg/mL
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
Quality Level
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General description
硫黄素T是苯并噻唑类染料，与淀粉样蛋白结合后荧光增强。 硫黄素T已可用于组织学和蛋白质表征。
Application
硫黄素T已被用来鉴别样品中淀粉样纤维的存在。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Sens. 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Ritu Khurana et al.
Journal of structural biology, 151(3), 229-238 (2005-08-30)
Thioflavin T is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In aqueous solutions, thioflavin T was found to exist as micelles
Extrinsic fluorescent dyes as tools for protein characterization.
Hawe, A., et al.
Pharmaceut. Res., 25, 1487-1499 (2008)
Pai Peng et al.
Nucleic acids research, 45(2), 541-546 (2016-12-03)
We present a conceptually new reversible nanosensor regulated by a DNA nanoswitch. This system is not only responsive to external stimuli (e.g. ATP) but also can be reversibly switched between 'OFF' and 'ON' states via toehold mediated strand displacement reactions.
Matthew Biancalana et al.
Biochimica et biophysica acta, 1804(7), 1405-1412 (2010-04-20)
Intense efforts to detect, diagnose, and analyze the kinetic and structural properties of amyloid fibrils have generated a powerful toolkit of amyloid-specific molecular probes. Since its first description in 1959, the fluorescent dye Thioflavin-T (ThT) has become among the most
G A Cornwall et al.
Andrology, 7(5), 603-609 (2019-01-22)
We previously demonstrated the normal mouse epididymal lumen contains a non-pathological amyloid matrix that surrounds spermatozoa and plays important roles in sperm maturation and protection. The objective herein was to present a review of this work, including studies showing the
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