产品名称
抗-β-微管蛋白III 兔抗, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~50 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
western blot: 1:500-1:1,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TUBB3(10381)
mouse ... Tubb3(22152)
rat ... Tubb3(246118)
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General description
微管是异二聚体蛋白,由α- 和β-微管蛋白组成。β-微管蛋白有多种不同的同种型。β-微管蛋白III是神经细胞分化以及静脉和淋巴管瓣的标志物。β-微管蛋白III表达的变化与成神经管细胞瘤有关
抗微管蛋白抗体可用于研究微管蛋白的定位。抗β微管蛋白III抗体具有人β-微管蛋白III特异性。
抗微管蛋白抗体可用于研究微管蛋白的定位。抗β微管蛋白III抗体具有人β-微管蛋白III特异性。
微管蛋白β 3 III类(TUBB3) 位于人类染色体 16q24.3。
Immunogen
对应人 β-微管蛋白 III 残基 151-165 的合成肽。
Application
抗 β-Tubulin III 抗体适用于流式细胞术 (1:200-1:500)、免疫组化 (1:100-1:200)、免疫印迹(约 50 kDa)和 免疫印迹(1:500-1:1,000)。
Biochem/physiol Actions
微管蛋白β3 III 类基因(TUBB3)中的错义突变影响神经元细胞的微管组织,并导致神经系统疾病。TUBB3 突变与导致发育中胎儿畸形的肾小管病变有关。
Physical form
溶剂为含有0.02%叠氮化钠的磷酸盐缓冲盐水。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
低风险生物材料
此项目有
Expression of neuron-specific β-III tubulin during olfactory neurogenesis in the embryonic and adult rat.
Roskams, A.,J., et al.
Neuroscience, 83(1), 191-200 (199)
Mutations in the neuronal beta-tubulin subunit TUBB3 result in malformation of cortical development and neuronal migration defects.
Poirier K, et al.
Human Molecular Genetics, 19(22), 4462-4473 (2010)
Seungkoo Lee et al.
European journal of cell biology, 84(2-3), 453-459 (2005-04-12)
Follicular dendritic cells (FDCs) play central roles in the B cell survival, proliferation, and differentiation into memory cells. Here, we show that TuJ1 (class III beta-tubulin) is expressed strongly in FDCs of human lymphoid tissue. TuJ1 has been a marker
Prognostic utility of beta-tubulin isotype III and correlations with other molecular and clinicopathological variables in patients with early breast cancer: a translational Hellenic Cooperative Oncology Group (HeCOG) study.
Pentheroudakis G, et al.
Breast Cancer Research and Treatment, 127(1), 179-193 (2011)
Valentina Caracciolo et al.
Journal of cellular physiology, 223(2), 519-529 (2010-02-18)
In previous studies, we have shown overexpression and ectopic subcellular distribution of gamma-tubulin and betaIII-tubulin in human glioblastomas and glioblastoma cell lines (Katsetos et al., 2006, J Neuropathol Exp Neurol 65:455-467; Katsetos et al., 2007, Neurochem Res 32:1387-1398). Here we
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