T4264
Tetrahydrozoline hydrochloride
≥98% (HPLC)
别名:
4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole monohydrochloride, Tetryzoline hydrochloride
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关于此项目
经验公式（希尔记法）:
C13H16N2 · HCl
化学文摘社编号:
分子量:
236.74
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
溶解性
H2O: freely soluble
alcohol: freely soluble
chloroform: very slightly soluble
diethyl ether: insoluble
创始人
Novartis
SMILES字符串
Cl.C1CC(C2=NCCN2)c3ccccc3C1
InChI
1S/C13H16N2.ClH/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13;/h1-2,4,6,12H,3,5,7-9H2,(H,14,15);1H
InChI key
BJORNXNYWNIWEY-UHFFFAOYSA-N
基因信息
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)
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相关类别
生化/生理作用
Tetrahydrozoline is an α-adrenergic agonist and an imidazoline derivative. It plays a crucial role in the constriction of conjunctival blood vessels. Tetrahydrozoline is a common component of nasal and eye drop formulations.
特点和优势
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Henry A Spiller et al.
Journal of forensic sciences, 57(3), 835-838 (2012-01-04)
Drug-facilitated sexual assault (DFSA) has been defined as the use of a chemical agent to facilitate a sexual assault. We report two cases of the use of tetrahydrozoline for DFSA. We believe this is the first report with urinary quantification
Mary E Carr et al.
Clinical toxicology (Philadelphia, Pa.), 49(9), 810-814 (2011-10-07)
No information exists on therapeutic or toxic concentrations of tetrahydrozoline, which has been reported to be used in drug facilitated sexual assaults. The primary aim of this investigation was to establish baseline therapeutic serum and urine concentrations in a sample
Aaron Daggy et al.
Veterinary and human toxicology, 45(4), 210-212 (2003-07-29)
Visine, an over-the-counter, tetrahydrozoline topical ophthalmic decongestant, possesses central and peripheral alpha2-adrenergic properties. We present a case of accidental pediatric oral exposure with resultant neurological and cardiovascular complications. Visine is not marketed in childproof containers, despite the potential severity of
Igor Kopac et al.
The International journal of prosthodontics, 15(1), 14-19 (2002-03-13)
The aim of this in vivo study on dogs was to investigate and compare the inflammatory potential of four different retraction agents on the gingival connective tissue. All procedures on eight beagle dogs were performed under general anesthesia: taking oral
P J Rice et al.
The Journal of pharmacology and experimental therapeutics, 259(3), 1182-1187 (1991-12-01)
Repeated exposure of the rat vas deferens to the imidazoline oxymetazoline (OXY) results in a progressive loss of response which can appear selective for imidazoline agonists. The present study tests the hypothesis that imidazolines produce desensitization through prolonged blockade or
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