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Merck
CN

T5391

Sigma-Aldrich

脱铁转铁蛋白 人

γ-irradiated, powder, BioXtra, suitable for cell culture, ≥98%

别名:

人转铁蛋白, 铁传递蛋白

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关于此项目

CAS Number:
11096-37-0
EC 号:
234-318-8
MDL编号:
MFCD00130536
UNSPSC代码:
12352202
NACRES:
NA.75

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质量水平

200

无菌性

γ-irradiated

产品线

BioXtra

方案

≥98%

表单

powder

分子量

76-81 kDa

浓度

~25 mM

技术

cell culture | mammalian: suitable

杂质

HIV and HBsAg, source material tested negative
 iron, essentially free

溶解性

H2O: 50 mg/mL

UniProt登记号

P02787

运输

wet ice

储存温度

−20°C

基因信息

human ... TF(7018)

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相关类别

一般描述

脱铁转铁蛋白（aTF）可以补充铁或用于结合培养基中存在的游离铁，它还可用于将铁运输到哺乳动物细胞中。

应用

脱铁转铁蛋白已作为补充剂：
  • 用于杜氏改良Eagle培养基/HamF12（DMEM/F-12），以培养人肾上腺皮质癌细胞
  • 在DMEM/F-12中培养小鼠神经前体细胞
  • 收集NCSU23培养基培养猪卵巢腔前卵泡

生化/生理作用

脱铁转铁蛋白（aTF）是一种内源性铁螯合剂，通过清除游离铁和防止有毒活性氧（ROS）的形成对宿主起到保护作用。它对地中海贫血有治疗作用。铁释放后，受体结合的脱铁转铁蛋白到达细胞表面，而不是被运输到溶酶体降解。细胞表面具有中性的pH值，促进脱铁转铁蛋白从受体释放，在此处再次循环并结合额外的铁，以进一步将铁传递到细胞。

其他说明

非血红素铁转运蛋白。

免责声明

供研究使用在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000302791
0000302791
SLCL4382
SLCD9280
SLBZ8722

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

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    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the carbohydrate content of human transferrin?

    We have found the information on transferrin in a reference book:The Plasma Proteins, F.W. Putnam, ed, volume 2, chapter 4, Table II.According to the table, Transferrin is 6 percent carbohydrate, citing G.A. Jamieson, J. Biol. Chem. 240(7), 2914-2920 (1965).The table also gives information on the percentage of each type of monosaccharide that is present.

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