T5701
抗-TSG101 兔抗
~2 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
抗-肿瘤易感基因101
登录 查看组织和合同定价。
选择尺寸
关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
western blot
western blot
Species reactivity:
rat, mouse, human
Citations:
52
Technique(s):
western blot: 0.5-1 μg/mL using cell lysates of rat fibroblast Rat-1 and mouse fibroblast NIH3T3 cells
western blot: 2-4 μg/mL using cell lysates of human A431 cells
western blot: 2-4 μg/mL using cell lysates of human A431 cells
Uniprot accession no.:
产品名称
抗-TSG101 兔抗, ~2 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 46 kDa
species reactivity
rat, mouse, human
concentration
~2 mg/mL
technique(s)
western blot: 0.5-1 μg/mL using cell lysates of rat fibroblast Rat-1 and mouse fibroblast NIH3T3 cells
western blot: 2-4 μg/mL using cell lysates of human A431 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TSG101(7251)
mouse ... Tsg101(22088)
rat ... Tsg101(292925)
Application
兔抗TSG101抗体可用于蛋白质印迹分析。
Biochem/physiol Actions
肿瘤易感性101（TSG101）涉及各种细胞功能，例如泛素化，转录调节，内体运输和细胞增殖。基因突变导致各种人类癌症。Tsg101在细胞生长、细胞存活以及胚胎和成人组织的正常功能中起着至关重要的作用。TSG101通过将p6晚期结构域与液泡蛋白分选机制连接来促进感染性人类免疫缺陷病毒（HIV-1）出芽。Tsg101是运输（ESCRT）机械所需的内体分选复合物的重要组成部分，有助于合成多囊泡体，主要是腔内囊泡的形成和分裂，因此对位在质膜上的受体的降解和再循环至关重要。Tsg101的表达受内在的自动调节机制和各种泛素连接酶催化的泛素化控制。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
肿瘤易感性101（TSG101）由定位于人类染色体11p15.1-15.2的基因编码。编码的蛋白质是催化失活的泛素E2变体（UEV）家族的成员。Tsg101的特征是在其N末端具有泛素E2变体（UEV）结构域，参与HIV-1出芽和液泡蛋白分选（VPS）途径。
Immunogen
合成肽对应于位于人TSG101的C端的氨基酸254-272，与KLH偶联。该序列在大鼠和小鼠TSG101中相同。
Physical form
溶于0.01 M磷酸盐缓冲液（pH 7.4）中，含有15 mM叠氮化钠。
未找到合适的产品？
试试我们的产品选型工具.
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Comparison of isolation methods of exosomes and exosomal RNA from cell culture medium and serum
Tang YT, et al.
International Journal of Molecular Medicine, 40(3), 834-844 (2017)
Owen Pornillos et al.
The EMBO journal, 21(10), 2397-2406 (2002-05-15)
Human Tsg101 plays key roles in HIV budding and in cellular vacuolar protein sorting (VPS). In performing these functions, Tsg101 binds both ubiquitin (Ub) and the PTAP tetrapeptide 'late domain' motif located within the viral Gag protein. These interactions are
Yue-Ting Tang et al.
International journal of molecular medicine, 40(3), 834-844 (2017-07-25)
Exosomes are cell-derived vesicles and are abundant in biological fluids; they contain RNA molecules which may serve as potential diagnostic biomarkers in 'precision medicine'. To promote the clinical application of exosomal RNA (exoRNA), many isolation methods must be compared and validated.
James V McCann et al.
Scientific reports, 9(1), 16743-16743 (2019-11-16)
Extracellular vesicles (EVs) play important roles in tumor progression by altering immune surveillance, promoting vascular dysfunction, and priming distant sites for organotropic metastases. The miRNA expression patterns in circulating EVs are important diagnostic tools in cancer. However, multiple cell types
Cancer-testis antigens MAGEA proteins are incorporated into extracellular vesicles released by cells
Kuldkepp A, et al.
Oncotarget, 10(38), 3694-3694 (2019)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持