T5701
抗-TSG101 兔抗
~2 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
抗-肿瘤易感基因101
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 46 kDa
species reactivity
rat, mouse, human
concentration
~2 mg/mL
technique(s)
western blot: 0.5-1 μg/mL using cell lysates of rat fibroblast Rat-1 and mouse fibroblast NIH3T3 cells, western blot: 2-4 μg/mL using cell lysates of human A431 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TSG101(7251)
mouse ... Tsg101(22088)
rat ... Tsg101(292925)
General description
肿瘤易感性101（TSG101）由定位于人类染色体11p15.1-15.2的基因编码。编码的蛋白质是催化失活的泛素E2变体（UEV）家族的成员。Tsg101的特征是在其N末端具有泛素E2变体（UEV）结构域，参与HIV-1出芽和液泡蛋白分选（VPS）途径。
Immunogen
合成肽对应于位于人TSG101的C端的氨基酸254-272，与KLH偶联。该序列在大鼠和小鼠TSG101中相同。
Application
兔抗TSG101抗体可用于蛋白质印迹分析。
Biochem/physiol Actions
肿瘤易感性101（TSG101）涉及各种细胞功能，例如泛素化，转录调节，内体运输和细胞增殖。基因突变导致各种人类癌症。Tsg101在细胞生长、细胞存活以及胚胎和成人组织的正常功能中起着至关重要的作用。TSG101通过将p6晚期结构域与液泡蛋白分选机制连接来促进感染性人类免疫缺陷病毒（HIV-1）出芽。Tsg101是运输（ESCRT）机械所需的内体分选复合物的重要组成部分，有助于合成多囊泡体，主要是腔内囊泡的形成和分裂，因此对位在质膜上的受体的降解和再循环至关重要。Tsg101的表达受内在的自动调节机制和各种泛素连接酶催化的泛素化控制。
Physical form
溶于0.01 M磷酸盐缓冲液（pH 7.4）中，含有15 mM叠氮化钠。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
未找到合适的产品？
试试我们的产品选型工具.
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
低风险生物材料
常规特殊物品
此项目有
Anna-Kristin Ludwig et al.
Journal of extracellular vesicles, 7(1), 1528109-1528109 (2018-10-26)
Extracellular vesicles (EVs) provide a complex means of intercellular signalling between cells at local and distant sites, both within and between different organs. According to their cell-type specific signatures, EVs can function as a novel class of biomarkers for a
James V McCann et al.
Scientific reports, 9(1), 16743-16743 (2019-11-16)
Extracellular vesicles (EVs) play important roles in tumor progression by altering immune surveillance, promoting vascular dysfunction, and priming distant sites for organotropic metastases. The miRNA expression patterns in circulating EVs are important diagnostic tools in cancer. However, multiple cell types
Kay-Uwe Wagner et al.
Molecular and cellular biology, 23(1), 150-162 (2002-12-17)
Tumor susceptibility gene 101 (Tsg101) was identified in a random mutagenesis screen for potential tumor suppressors in NIH 3T3 cells. Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. However, the involvement
Cancer-testis antigens MAGEA proteins are incorporated into extracellular vesicles released by cells
Kuldkepp A, et al.
Oncotarget, 10(38), 3694-3694 (2019)
Olga Dolnik et al.
PLoS pathogens, 10(10), e1004463-e1004463 (2014-10-21)
Endosomal sorting complex required for transport (ESCRT) machinery supports the efficient budding of Marburg virus (MARV) and many other enveloped viruses. Interaction between components of the ESCRT machinery and viral proteins is predominantly mediated by short tetrapeptide motifs, known as
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持