T5826
Anti-TSG101 (N-terminal) antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-Tumor Susceptibility Gene 101
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 46 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
microarray: suitable, western blot: 1-2 μg/mL using cell lysates of rat fibroblast Rat-1, mouse fibroblast NIH3T3, and human A431 cells, and rat brain extract (S1 cytosolic fraction)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TSG101(7251)
mouse ... Tsg101(22088)
rat ... Tsg101(292925)
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General description
Tumor susceptibility gene 101 protein (TSG101) is mapped to human chromosome 11p15.1. TSG101 has ubiquitin E2 variant domain.
Immunogen
synthetic peptide corresponding amino acids 2-20 located at the N-terminus of human TSG101, conjugated to KLH. This sequence is identical in rat and mouse TSG101.
Biochem/physiol Actions
Tumor susceptibility gene 101 protein (TSG101) is a component of endosomal sorting complex required for transport (ESCRT) machinery. TSG101 interacts with arrestin domain-containing protein 1 and mediates its budding through plasma membrane. It binds to ubiquitinylated proteins and conveys them for degradation by lysosomes. TSG101 is also essential for the budding human immunodeficiency virus (HIV) infected cells. TSG101 deficiency is associated with genome instability and is considered as a risk factor for tumor initiation.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
低风险生物材料
此项目有
Ubiquitin recognition by the human TSG101 protein
Sundquist WI, et al.
Molecular Cell, 13(6), 783-789 (2004)
Cell cycle-dependent subcellular localization of the TSG101 protein and mitotic and nuclear abnormalities associated with TSG101 deficiency
Xie W, et al.
Proceedings of the National Academy of Sciences of the USA, 95(4), 1595-1600 (1998)
Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
Garrus JE, et al.
Cell, 107(1), 55-65 (2001)
Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein.
Nabhan JF, et al.
Proceedings of the National Academy of Sciences of the USA, 109(11), 4146-4151 (2012)
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