T8575
Anti-Tryptophan Hydroxylase Antibody
sheep polyclonal
别名:
抗-TPH
产品名称
抗-色氨酸羟化酶 绵羊抗, affinity isolated antibody, buffered aqueous glycerol solution
biological source
sheep
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
usage
sufficient for 10 blots
species reactivity
mammals, human
technique(s)
western blot: 1:1,000 using human dorsal raphe nucleus
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
human ... TPH1(7166)
mouse ... Tph1(21990)
rat ... Tph1(24848)
General description
色氨酸羟化酶1（TPH1）基因跨越29kbp，具有11个外显子，定位于人染色体11p15.3-p14。TPH1是在肠道、脾脏、胸腺以及松果体和垂体中表达的444个氨基酸蛋白。
色氨酸羟化酶（TPH）是芳香族氨基酸羟化酶（AAAH）家族的成员。
Immunogen
重组兔色氨酸羟化酶，从大肠埃希菌中分离为包涵体，并通过制备性SDS-PAGE纯化。
Application
绵羊抗色氨酸羟化酶抗体可用于：
- 免疫细胞化学
- 免疫组织化学
- 免疫荧光
- 免疫过氧化物酶染色
Biochem/physiol Actions
色氨酸羟化酶1基因（TPH1）催化5-羟色氨酸的合成，而5-羟色氨酸是神经递质5-羟色胺的前体。基因表达的变化会影响反应抑制过程中前额叶皮层的激活。TPH1基因的突变会导致精神分裂症，女性肠易激综合征（IBS），自杀行为和抑郁症。编码的蛋白质在调节心血管功能中起着至关重要的作用。
Physical form
溶于150 mM NaCl，10 mM HEPES，pH 7.5，100 μg/mL BSA和50%甘油。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
低风险生物材料
常规特殊物品
此项目有
R C Drugan et al.
Neuroscience, 253, 221-234 (2013-09-04)
Prior adverse experience alters behavioral responses to subsequent stressors. For example, exposure to a brief swim increases immobility in a subsequent swim test 24h later. In order to determine if qualitative differences (e.g. 19°C versus 25°C) in an initial stressor
Matthew W Hale et al.
Journal of chemical neuroanatomy, 41(4), 219-226 (2011-06-07)
Tryptophan hydroxylase is the rate-limiting enzyme in the biosynthesis of serotonin (5-hydroxytryptamine; 5-HT). Two isoforms of tryptophan hydroxylase, derived from different genes, tph1 and tph2, have been identified. The tph1 isoform is expressed in peripheral tissues, whereas tph2 is brain
Tryptophan hydroxylase 1 gene polymorphisms alter prefrontal cortex activation during response inhibition.
Ruocco AC
Neuropsychology, 30, 18-27 (2016)
Rachel A Walker et al.
The European journal of neuroscience, 51(3), 866-880 (2019-08-04)
Aversive, positive prediction error (+PE) provides a mechanism to update and increase future fear to uncertain threat predictors. The ventrolateral periaqueductal grey (vlPAG) has been offered as a neural locus for +PE computation. Yet, a causal demonstration of vlPAG +PE
Kristina M Wright et al.
eLife, 8 (2019-03-08)
Faced with potential harm, individuals must estimate the probability of threat and initiate an appropriate fear response. In the prevailing view, threat probability estimates are relayed to the ventrolateral periaqueductal gray (vlPAG) to organize fear output. A straightforward prediction is
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