T9030
单克隆抗-肌联蛋白 小鼠抗
clone T11, purified from hybridoma cell culture
别名:
Monoclonal Anti-Titin antibody produced in mouse, Anti-CMD1G, Anti-CMH9, Anti-CMPD4, Anti-EOMFC, Anti-HMERF, Anti-LGMD2J, Anti-LGMDR10, Anti-MYLK5, Anti-SALMY, Anti-TMD
产品名称
单克隆抗-肌联蛋白 小鼠抗, clone T11, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
T11, monoclonal
contains
15 mM sodium azide
species reactivity
vertebrates, chicken
technique(s)
electron microscopy: suitable
immunohistochemistry (frozen sections): suitable
indirect immunofluorescence: 1:1,000 using frozen tissue sections of animal skeletal muscle
western blot: suitable
isotype
IgG2b
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
chicken ... TTN(424126)
Application
在小鼠中生产的单克隆抗肌联蛋白抗体已用于以下研究。
- 蛋白质印迹
- 抗体染色
- 免疫荧光显微镜
- 免疫组化
Biochem/physiol Actions
单克隆抗肌联蛋白可用于研究肌节结构内的弹性丝。它也可用作横纹肌肉瘤与其他肌肉肿瘤分离的分化标记。
肌联蛋白（TTN）通过与许多其他肌原纤维和细胞骨架蛋白相互作用来帮助维持肌节结构完整性。此外，它还参与了肌肉被动弹力的发展。该基因的遗传变异与扩张型心肌病（DCM）的发展有关。
该抗体将肌联蛋白（连接蛋白）定位在从冷血脊椎动物到人类的各种物种的骨骼肌和心肌中。 该抗体不与伴肌动蛋白发生交叉反应。同样，它不与平滑肌、非肌肉组织或培养的细胞反应。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
单克隆抗肌联蛋白（小鼠IgG2b亚型）来自于免疫小鼠骨髓瘤细胞和脾细胞相互融合而产生的杂交瘤细胞。它是横纹肌的柔性丝状成分，被认为会在肌原纤维组织下面产生弹性细丝成分。
肌联蛋白（TTN），也称为连接蛋白，由定位于人类染色体2q31.2的基因编码。TTN是在脊椎动物的横纹肌和平滑肌中表达的巨大弹性蛋白。编码的蛋白质包含多达300个免疫球蛋白样和纤连蛋白3型（FN3）结构域。
Immunogen
鸡胸肌中的肌联蛋白/伴肌动蛋白部分。
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Stephan Lange et al.
JCI insight, 4(19) (2019-09-13)
Perturbations in biomechanical stimuli during cardiac development contribute to congenital cardiac defects such as hypoplastic left heart syndrome (HLHS). This study sought to identify stretch-responsive pathways involved in cardiac development. miRNA-Seq identified miR-486 as being increased in cardiomyocytes exposed to
Elastic domains of giant proteins in striated muscle: Modeling compliance with rulers
Chase PB
The Journal of General Physiology, 151(5), 619-622 (2019)
Gigantic variety: expression patterns of titin isoforms in striated muscles and consequences for myofibrillar passive stiffness
Neagoe C
Journal of Muscle Research and Cell Motility, 24, 175-189 (2003)
Some distinctive features of zebrafish myogenesis based on unexpected distributions of the muscle cytoskeletal proteins actin, myosin, desmin, ?-actinin, troponin and titin
Costa ML
Mechanisms of Development, 116, 95-104 (2002)
Genome-wide linkage scan for maximum and length-dependent knee muscle strength in young men: significant evidence for linkage at chromosome 14q24.3
De Mars G
Journal of medical Genetics, 45, 275-283 (2008)
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