U6508
UCN-01
≥97% (HPLC), PKC inhibitor, powder
别名:
KW-2401
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关于此项目
经验公式（希尔记法）:
C28H26N4O4
CAS Number:
分子量:
482.53
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
Product Name
UCN-01, ≥97% (HPLC), powder
质量水平
方案
≥97% (HPLC)
表单
powder
旋光性
[α]20/D 130 to 160°, c = 0.2 in DMSO
储存条件
protect from light
颜色
light yellow
溶解性
DMSO: >5 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
[H][C@@]1(C[C@@H](NC)[C@H]2OC)N3C4=C(N([C@@]2(C)O1)C5=C6C=CC=C5)C6=C7C(C(N[C@@H]7O)=O)=C4C8=C3C=CC=C8
InChI
1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27-,28+/m1/s1
InChI key
PBCZSGKMGDDXIJ-HQCWYSJUSA-N
基因信息
应用
UCN-01 has been used to study checkpoint kinase-1 (CHK1) protein function in trophoblast stem (TS) cells. It has also been used to study UV-induced CHK1 phosphorylation in IB10 cells.
生化/生理作用
UCN-01 is a selective inhibitor for conventional PKC isotypes over novel PKC isotypes.
特点和优势
This compound is featured on the PKB/Akt and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
制备说明
UCN-01 is soluble in DMSO at a concentration that is greater than 5 mg/ml. However, it is insoluble in water.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
S Akinaga et al.
Anti-cancer drug design, 15(1), 43-52 (2000-07-11)
UCN-01 (7-hydroxystaurosporine) is a protein kinase inhibitor which is under development as an anti-cancer agent in the USA and Japan. Although UCN-01 was originally isolated from the culture broth of Streptomyces sp. as a protein kinase C-selective inhibitor, its ultimate
Eiichi Fuse et al.
Journal of clinical pharmacology, 45(4), 394-403 (2005-03-22)
UCN-01 is a protein kinase inhibitor under development as a novel anticancer drug. The initial pharmacologic features in patients were not predicted from preclinical experiments. The distribution volume and the systemic clearance were much lower than those in experimental animals
Adrian M Senderowicz
The oncologist, 7 Suppl 3, 12-19 (2002-08-08)
Many tumor types are associated with genetic changes in the retinoblastoma pathway, leading to hyperactivation of cyclin-dependent kinases and incorrect progression through the cell cycle. Small-molecule cyclin-dependent kinase inhibitors are being developed as therapeutic agents. Of these, flavopiridol and UCN-01
Wuli Zhao et al.
Journal of experimental & clinical cancer research : CR, 37(1), 98-98 (2018-05-08)
A35 is a novel synthetic cyclizing-berberine recently patented as an antitumor compound. Based on its dual targeting topoisomerase (top) activity, A35 might overcome the resistance of single-target top inhibitors and has no cardiac toxicity for not targeting top2β. In this
Sung-Bau Lee et al.
Science advances, 4(8), eaat4985-eaat4985 (2018-08-14)
DNA sequence and epigenetic information embedded in chromatin must be faithfully duplicated and transmitted to daughter cells during cell division. However, how chromatin assembly and DNA replication are integrated remains unclear. We examined the contribution of the Tousled-like kinases 1
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