U6750
尿苷-5′-三磷酸酯 三钠盐 水合物
≥93.0% (HPLC), Thyroid hormone
别名:
UTP Na3
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关于此项目
经验公式（希尔记法）:
C9H12N2Na3O15P3 · xH2O
化学文摘社编号:
分子量:
550.09 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
243-347-5
MDL number:
Beilstein/REAXYS Number:
3585234
产品名称
尿苷-5′-三磷酸酯 三钠盐 水合物, Type IV, ≥93.0% (HPLC)
InChI key
MMJGIWFJVDOPJF-LLWADOMFSA-K
InChI
1S/C9H15N2O15P3.3Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1
SMILES string
[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O
type
Type IV
assay
≥93.0% (HPLC)
solubility
H2O: soluble 25 mg of UTP in 0.5 ml of solvent, clear, colorless
storage temp.
−20°C
Quality Level
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Application
UTP 已被用作 P2 受体激活剂，研究其对 MC3T3-E1 和 UMR-106 细胞质子外流的影响 。还研究了 UTP 与盐酸阿米洛利雾化溶液联合治疗囊性纤维化 。
尿苷 5′-三磷酸盐曾用于一项研究显示氟西汀 (FLX) 通过增加腺苷 5′ 的胶质传递而介导其抗抑郁作用-三磷酸盐 (ATP)。
Biochem/physiol Actions
P2Y 受体激动剂。
尿苷-5′-三磷酸盐 (UTP) 是核酸的细胞溶质核苷酸成分。作为细胞外间隙中的信号分子。尿苷-5′-三磷酸盐 (UTP) 参与神经系统的多种病理生理反应。UTP 在再生过程中也起主要角色。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
Preparation Note
25 mg 尿苷 5'-三磷酸三钠盐 (UTP Na 3 ) 水合物可溶于 0.5 mL 水中，并产生澄清、无色溶液。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Journal of pharmaceutical sciences, 93(9), 2399-2406 (2004-08-06)
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